二咖啡酰奎宁酸类天然产物植物来源、药动学及生物活性的研究进展  

Research progress on plant origins, pharmacokinetics, and biological activities of natural dicaffeoylquinic acids

作　　者：韩亚如 马国力 韩亚龙 高嘉敏 折占飞 冯玉宝 肖斌 HAN Ya-ru;MA Guo-li;HAN Ya-long;GAO Jia-min;SHE Zhan-fei;FENG Yu-bao;XIAO Bin(Laboratory of Clinical Pharmacy,Ordos School of Clinical Medicine,Inner Mongolia Medical University,Ordos 017000,China;The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150040,China)

机构地区：[1]内蒙古医科大学,鄂尔多斯临床医学院,临床药学实验室,内蒙古鄂尔多斯017000 [2]哈尔滨医科大学附属肿瘤医院,黑龙江哈尔滨150040

出　　处：《中草药》2023年第4期1285-1298,共14页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金地区基金项目(82260822);中央引导地方科技发展资金项目(2020ZY0036);中国科学院“西部之光”青年学者资助项目(人字[2020]82号);内蒙古自治区自然科学基金面上项目(2022MS08034);内蒙古自治区卫生健康委员会医疗卫生科技计划项目(202202379);鄂尔多斯市科技计划项目(鄂财教指[2019]501号)。

摘　　要：随着生活水平的不断提高,高脂、高蛋白饮食导致癌症、心脑血管疾病、过敏性疾病已成为威胁人类健康的主要病因,其中抗氧化、清除自由基是重要的预防和治疗方式之一。二咖啡酰奎宁酸类化合物在自然界分布广泛,具有多酚羟基结构,生理活性多样,包括抗氧化、抗炎、降血糖、调血脂、抑制血小板、抗微生物、抗肿瘤等,引起国内外众多学者的广泛关注。由于理化性质及药动学影响,其药物开发并不完善。通过对二咖啡酰奎宁酸类化合物的植物来源、药动学以及生物活性研究进展进行综述,以期为其开发利用提供依据。With the continuous improvement of the living standard, high-fat and high-protein diet leading to cancer, cardiovascular and cerebrovascular diseases, and allergic diseases have become the main causes of threats to human health, of which antioxidant and free radical scavenging is one of the important prevention and treatment methods. Dicaffeoylquinic acids are widely distributed in nature,with polyphenol structure and various physiological functions including antioxidant, anti-inflammatory, hypoglycemic, lipid-lowering,platelet inhibitory, antimicrobial and anti-tumor, etc., which have attracted extensive attention from many scholars at home and abroad.Due to the influence of physicochemical properties and pharmacokinetics, its drug development is not perfect. In this paper, the plant origins, pharmacokinetics, and biological activities of natural dicaffeoylquinic acids were reviewed to provide basis for their development and utilization.

关 键 词：二咖啡酰奎宁酸 心脑血管疾病 植物来源 药动学 抗氧化 开发利用 

分 类 号：R285[医药卫生—中药学]