天然高聚物基手术缝合线的研究现状  

Research status of natural polymer-based surgical sutures

作　　者：杨鑫 张昕[1] 潘志娟[1,2] YANG Xin;ZHANG Xin;PAN Zhijuan(College of Textile and Clothing Engineering,Soochow University,Suzhou 215021,China;National Engineering Laboratory for Modern Silk,Suzhou 215123,China)

机构地区：[1]苏州大学纺织与服装工程学院,江苏苏州215021 [2]现代丝绸国家工程实验室,江苏苏州215123

出　　处：《丝绸》2023年第3期1-7,共7页Journal of Silk

摘　　要：医用手术缝合线种类丰富,其制备原料可分为天然材料、合成材料及金属材料等,其中天然高聚物基手术缝合线以其优异的生物相容性、低免疫原性等特性在市场上占据主体地位,但仍存在机械性能较差、降解速率难以调控等问题。为了改善天然高聚物基缝合线的性能,促进新型缝合线的研究发展,并使其进一步满足医用领域的应用需求,本文综述了蚕丝基、胶原基、甲壳素基三类天然高聚物基缝合线的研究现状,比较了三者在实际应用中的优缺点,并分析了三者存在的性能缺陷及改进方向,以期为天然高聚物基手术缝合线的研究发展提供参考。The surgical suture,a kind of medical material used to suture wound and connective tissue in surgery,is also the most common implantable material.Medical-surgical sutures are abundant in raw materials,including natural materials,synthetic materials and metal materials.Among them,natural polymer-based surgical sutures occupy a dominant position in the market due to their excellent biocompatibility,low immunogenicity and other characteristics.However,there are still some problems,such as poor mechanical properties and difficulty in regulating the degradation rate.In order to improve the property of natural polymer-based sutures and promote the development and application of new sutures,we summarize the research status of silk-based sutures,collagen-based sutures and chitin-based sutures.We compare their merit and demerit in practical application and analyze their existing performance defects and improvement direction,so as to provide a reference for the development of natural polymer-based surgical sutures.Silk-based sutures have a long history of application in the field of sutures because of their excellent hygroscopic properties,operability and knotting stability.However,the disadvantages of monofilament sutures such as poor biodegradability and susceptibility to infection limit the application of silk sutures.Therefore,medical silk sutures generally require antibacterial treatment.The common method is to load antibacterial coatings on the surface of the sutures and new coatings capable of broad-spectrum bactericidal and drug slow-release functions are still being explored.Most of the studies domestically and overseas focus on the improvement of coating modification methods,while there are few studies on the improvement of fiber properties.Based on silk fibers,researchers can improve the performance of the fiber and endow it with special functions such as antibacterial function in future studies,which can effectively improve the performance of silk sutures and expand their application ranges.As an absorbable med

关 键 词：天然高聚物 手术缝合线 蚕丝 胶原蛋白 甲壳素 壳聚糖 

分 类 号：TS101.4[轻工技术与工程—纺织工程]