核心抗体阳性献血者的跟踪研究  

Blood donors with HBV core anti-body:a follow-up study

作　　者：周璐[1] 王东[1] 臧亮[1] 邓雪莲[1] ZHOU Lu;WANG Dong;ZANG Liang;DENG Xuelian(Dalian Blood Center,Dalian 116001,China)

机构地区：[1]大连市血液中心,辽宁大连116001

出　　处：《中国输血杂志》2023年第2期141-144,共4页Chinese Journal of Blood Transfusion

基　　金：中国输血协会圣湘输血医学发展基金(CSBT-SX-2021-02);大连市医学科学研究计划项目(1711091)。

摘　　要：目的通过跟踪核心抗体(抗-HBc)阳性献血者再次献血时的HBV检测结果,评价抗-HBc在现有的HBV血液筛查策略下对于血液安全的意义。方法随机留取大连市血液中心采集血液的血浆标本。采用ELISA法检测抗-HBc(2种试剂)和抗-HBs。对抗-HBc+血液筛查合格献血者的再次献血和HBV筛查反应性献血者随访的情况进行跟踪。结果2017年5月~2018年3月随机留取了1291份血浆标本。其中抗-HBc+标本405份(31.4%)。抗-HBc+献血者年龄中位数(39岁)高于抗-HBc-献血者(31岁)(P<0.05),性别、首次/重复献血者比例无差异(P>0.05)。在405位抗-HBc+献血者中确证OBI 3人(0.7%),其中1人在再次献血时被确证。3位OBI献血者在随访中均不能检出HBV DNA。结论鉴于抗-HBc+献血者的比例较高,目前仍不具备将抗-HBc检测纳入血液筛查的条件,但抗-HBc检测对于HBV筛查反应性的献血者归队评估有着重要的应用价值。Objective To evaluate the role of anti-HBc detection in current blood screening strategy by the follow-up of repeated donors with antibody to hepatitis B virus core antigen.Methods Plasma samples were collected randomly from Dalian Blood Center.to test anti-HBc(dual reagents)and anti-HBs via ELISA.The re-donation of eligible donors who were anti-HBc+and donors reactive to HBV detection were followed up.Results A total of 1291 plasma samples were collected randomly from May 2017 to March 2018,among which 405 samples(31.4%)were anti-HBc+.The median age of anti-HBc+group was observed much higher than that of anti-HBc-group(39 vs 31 years old)(P<0.05),but no significant difference was noticed in gender nor the proportion of first-time/repeated blood donors(P>0.05).Among the 405 anti-HBc+donors,3 donors were OBI(0.7%),of which one was screened out in second donation.No HBV DNA was detected out in 3 OBI cases.Conclusion Although anti-HBc detection is not suitable in blood screening currently,it is of great value in the assessment of blood donor re-entry for HBV reactive donors in blood screening due to the high anti-HBc prevalence among blood donors.

关 键 词：隐匿性乙型肝炎病毒感染 乙肝病毒核心抗体 核酸检测 献血者归队 

分 类 号：R457.1[医药卫生—治疗学] R373.2[医药卫生—临床医学] R446