胰腺癌患者ABO血型分布相关性研究  

Study on the distribution of ABO blood group in patients with pancreatic cancer

作　　者：杨孝亮 周小琴 李静 仲霞 王坤 唐晓燕 顾星 YANG Xiaoliang;ZHOU Xiaoqin;LI Jing;ZHONG Xia;WANG Kun;TANG Xiaoyan;GU Xing(Department of Blood Transfusion,The Third Affiliated Hospital of Naval Military Medical University,Shanghai 201805,China;Area B of the First Department of Interventional Radiology,The Third Affiliated Hospital of Naval Military Medical University,Shanghai 201805,China;One Ward of the Second Department of Extrahepatic Surgery,The Third Affiliated Hospital of Naval Military Medical University,Shanghai 201805,China;Department of Laboratory Diagnosis,Jiading Campus,The Third Affiliated Hospital of Naval Military Medical University,Shanghai 201805,China)

机构地区：[1]海军军医大学第三附属医院嘉定院区输血科,上海201805 [2]海军军医大学第三附属医院嘉定院区放射介入一科B区,上海201805 [3]海军军医大学第三附属医院嘉定院区肝外二科一病区,上海201805 [4]海军军医大学第三附属医院嘉定院区实验诊断科,上海201805

出　　处：《中国输血杂志》2023年第2期152-155,共4页Chinese Journal of Blood Transfusion

基　　金：孟超人才计划—支撑平台学科青年人才培训计划。

摘　　要：目的探讨胰腺癌患者ABO血型分布差异是否存在相关性并评估相对危险性。方法选取本院2017年1月~2021年10月行ABO血型检测的病理诊断或出院诊断为胰腺癌的患者,分析患者血型分布情况及其相关性的研究。结果胰腺癌组与对照组分布差异有统计学意义(P<0.05);研究显示A型可能是胰腺癌患者的相对危险因素(χ^(2)=42.44,P<0.001),B型可能起到保护作用(χ^(2)=16.28,P<0.01)。不同性别组中分布差异也有显著差异(χ^(2)=64.35,P<0.05),检测结果男性中A型可能是胰腺癌的危险因素(χ^(2)=35.2,OR=1.7,95%CI=0.59~1.02,P<0.001),O型则可能起到保护作用(χ^(2)=18.22,OR=0.6,95%CI=0.25~0.32,P<0.01);女性检测结果分布中A型可能是胰腺癌患者的相对危险因素(χ^(2)=7.06,OR=1.4,95%CI=0.59~1.02,P<0.001),B型则可能起到保护作用(χ^(2)=20.32,OR=0.5,95%CI=0.32~0.43,P<0.01)。胰腺癌组血型分类中危险因素A型高出非A型组,起到保护作用的B型明显高出非B型组患者。结论胰腺癌患者中血型分布以及存在相对危险因素提示均已A型为主;在A血型的人群中有已明确胰腺癌的影响因素应该更加足以重视,早预防,早治疗,从而来降低发病的风险。Objective To investigate whether there is a correlation between the differences in ABO blood group distribution in patients with pancreatic cancer,and to evaluate the relative risk.Methods Patients with pathological diagnosis or discharge diagnosis of pancreatic cancer who underwent ABO blood group typing in our hospital from January 2017 to October 2021 were selected,and the blood group distribution of patients and the correlation were analyzed.Results There was a statistically significant difference between the pancreatic cancer group and the control group(P<0.05).The study showed that type A may be a relative risk factor for pancreatic cancer patients(χ^(2)=42.44,P<0.001),and type B may play a protective role(χ^(2)=16.28,P<0.01).Significant differences were found in distribution between different gender groups(χ^(2)=64.35,P<0.05).The test results showed that type A may be a risk factor for pancreatic cancer in men(χ^(2)=35.2,OR=1.7,95%CI=0.59-1.02,P<0.001),and type O may play a protective role in pancreatic cancer(χ^(2)=18.22,OR=0.6,95%CI=0.25-0.32,P<0.01);type A may be a relative risk factor for female pancreatic cancer patients(χ^(2)=7.06,OR=1.4,95%CI=0.59-1.02,P<0.001),while type B may play a protective role(χ^(2)=20.32,OR=0.5,95%CI=0.32-0.43,P<0.01).In pancreatic cancer group,the risk factors of blood type A were higher than those of non-A group,and the protective effect of type B was significantly higher than that of non-B group.Conclusion The distribution of blood group and relative risk factors in pancreatic cancer patients suggest that A type is predominant;in the population with A blood group,more attention should be paid to early prevention and early treatment,so as to reduce the risk of disease.

关 键 词：消化道肿瘤 胰腺癌 血型分布 

分 类 号：R457.11[医药卫生—治疗学] R576[医药卫生—临床医学]