我国18家地市级血站献血人群HBV感染情况分析  

HBV infection among blood donors from 18 domestic blood stations of prefecture-level cities

作　　者：王丁丁 沈有华 钟建玲 张翙 田志彬 鲍琳 赵会霞 张剑 汪鹏 何燕琴 张微 李丽[12] 李浩 褚德旭 王颖 张鑫 许守广 黄敏[18] 邱艳[19] WANG Dingding;SHEN Youhua;ZHONG Jianling;ZHANG Hui;TIAN Zhibin;BAO Lin;ZHAO Huixia;ZHANG Jian;WANG Peng;HE Yanqin;ZHANG Wei;LI Li;LI Hao;CHU Dexu;WANG Ying;ZHANG Xin;XU Shouguang;HUANG Min;QIU Yan(Handan Blood Station,Handan 056001,China;Shangrao Blood Station;Xianyang Blood Station;Nanning Blood Station;Puyang Blood Station;Yichun Blood Station;Qingdao Blood Station;Yancheng Blood Station;Bijie Blood Station;Ganzhou Blood Station;Beijing Tongzhou Blood Station;Huaian Blood Station;Chengde Blood Station;Chifeng Blood Station;Baoding Blood Station;Xingtai Blood Station;Yangzhou Blood Station;Nanjing Red Cross Blood Center;Beijing Red Cross Blood Center)

机构地区：[1]邯郸市中心血站,河北邯郸056001 [2]上饶市中心血站 [3]咸阳市中心血站 [4]南宁中心血站 [5]濮阳市中心血站 [6]宜春市中心血站 [7]青岛市中心血站 [8]盐城市中心血站 [9]毕节市中心血站 [10]赣州市中心血站 [11]北京市通州区中心血站 [12]淮安市中心血站 [13]承德市中心血站 [14]赤峰市中心血站 [15]保定市中心血站 [16]邢台市中心血站 [17]扬州市中心血站 [18]南京红十字血液中心 [19]北京市红十字血液中心

出　　处：《中国输血杂志》2023年第2期172-176,共5页Chinese Journal of Blood Transfusion

摘　　要：目的通过分析18家地市级血站(简称血站)献血者血液乙型肝炎病毒(HBV)检测相关数据,了解献血人群HBV感染情况。方法通过中国内地采供血执业比对平台,收集2017~2020年国内18家血站献血者血液HBV检测不合格率和不合格地区分布特征、初次献血者和重复献血者HBsAg ELISA不合格率、HBsAg ELISA合格但HBV DNA不合格(简称HBV DNA单独不合格)的献血者比率等相关数据,并统计分析献血人群HBV感染情况。结果2017~2020年18家血站的献血者HBV不合格率为13.48/万~144.02/万,其中东部地区HBV不合格率平均为26.14/万,中部地区为51.98/万,西部地区为41.00/万;初次献血者HBsAg ELISA不合格率为14.55/万~305.39/万;重复献血者HBsAg ELISA不合格率为1.04/万~87.43/万;HBV DNA单独不合格率为1.80/万~35.31/万。结论献血人群HBV感染分布具有地域性;重复献血者为低危献血人群;HBsAg ELISA和HBV DNA联合检测可以最大限度保障血液安全。Objective To analyze the hepatitis B virus(HBV)infection data of blood donors from 18 domestic blood stations,so as to investigate the HBV infection situation of blood donors.Methods The positive rate of HBV and its distribution characteristics of regions,the percentage of HBsAg+ELISA in first-time vs repeated blood donors,and the percentage of HBsAg-/HBV DNA+blood donors of 18 domestic blood stations during 2017 to 2020 were collected from the Working Platform for Practice Comparison of Blood Centers,and the HBV infection among blood donors were statistically analyzed.Results From 2017 to 2020,the positive rate of HBV in blood donors among 18 domestic blood stations was 13.48/10000-144.02/10000,with the average HBV positive rate in eastern,central and western region at 26.14/10000,51.98/10000 and 41.00/10000,respectively.The HBsAg+rate by ELISA among first-time and repeated blood donors was 14.55/10000-305.39/10000 vs 1.04/10000-87.43/10000 The HBsAg-/HBV DNA+yield was 1.80/10000-35.31/10000.Conclusion The distribution of HBV infection in blood donors has regional characteristics,and HBV prevalence was low in repeated blood donors.HBsAg ELISA combined with HBV DNA detection can better ensure blood safety.

关 键 词：献血者 乙型肝炎病毒 不合格率 初次献血者 重复献血者 HBsAg ELISA HBV DNA 

分 类 号：R457.1[医药卫生—治疗学] R446[医药卫生—临床医学] R373.2