卡维地洛联合瑞伐他汀对高血压合并冠脉粥样硬化患者CTGF、Lp-PLA2水平的疗效观察  

Effect of carvedilol combined with revastatin on levels of connective tissue growth factor and lipoprotein associated phospholipase A2 in patients with hypertension complicated by coronary atherosclerosis

作　　者：马良[1] 谭慧[1] 郭明凯 杜玮玮 宋宝珠[2] 周清和 Ma Liang;Tan Hui;Guo Mingkai;Du Weiwei;Song Baozhu;Zhou Qinghe(Department of Cardiovascular Medicine,Huanghe Sanmenxia Hospital,Henan Province,Sanmenxia 472000,China;不详)

机构地区：[1]河南省黄河三门峡医院心血管内科,三门峡472000 [2]黄河三门峡医院心脏重症监护室,三门峡472000 [3]三门峡市120急救中心,三门峡472000

出　　处：《中国循证心血管医学杂志》2022年第12期1484-1486,1491,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：中国水利水电第十一工程局有限公司科技项目(2017-157)。

摘　　要：目的 研究卡维地洛联合瑞伐他汀对高血压合并冠状动脉(冠脉)粥样硬化患者结缔组织生长因子(CTGF)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平的疗效观察。方法 选取2018年7月至2019年7月于黄河三门峡医院心内科收治的高血压合并冠脉粥样硬化患者156例作为研究对象,随机分为对照组和观察组,每组各78例。两组均行经皮冠脉介入治疗(PCI),抑制血小板聚集、降压等常规治疗,术前7 d均服用阿司匹林100 mg,1/d。对照组应用瑞伐他汀治疗,观察组应用瑞伐他汀联合卡维地洛治疗。采用酶联免疫吸附法检测血清三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)水平;采用免疫荧光定量法检测CTGF、Lp-PLA2水平。评价两组的不良反应及临床疗效。结果与对照组比较,观察组TG、TC、收缩压(SBP)、舒张压(DBP)、CTGF、Lp-PLA2水平均显著降低,差异有统计学意义(P<0.05);与对照组比较,观察组HDL-C水平显著升高,差异有统计学意义(P<0.05);与对照组相比,观察组治疗总有效率较高,差异有统计学意义(P<0.05)。结论 卡维地洛联合瑞伐他汀治疗可改善高血压合并冠脉粥样硬化患者的症状,提高CTGF、Lp-PLA2水平。Objective To study the effect of carvedilol combined with revastatin on levels of connective tissue growth factor(CTGF) and lipoprotein associated phospholipase A2(Lp-PLA2) in patients with hypertension complicated by coronary atherosclerosis. Methods The patients with hypertension complicated by coronary atherosclerosis(n=156) were chosen from Department of Cardiovascular Medicine in Huanghe Sanmenxia Hospital from July 2018 to July 2019, and divided randomly into control group and observation group(each n=78). All groups were given therapies of percutaneous coronary intervention(PCI), platelet aggregation inhibition and blood pressure reduction, and also given orally aspirin(100 mg) once a day before PCI. The control group was treated with revastatin and observation group was treated with carvedilol combined with revastatin. The levels of triglyceride(TG),high-density lipoprotein-cholesterol(HDL-C) and total cholesterol(TC) were detected by using ELISA. The levels of CTGF and Lp-PLA2 were detected by using quantitative immunofluorescence. The adverse reactions and clinical efficacy were reviewed in 2 groups. Results The levels of TG, TC, systolic blood pressure(SBP), diastolic blood pressure(DBP), CTGF and Lp-PLA2 decreased significantly in observation group compared with control group(P<0.05). The level of HDL-C increased significantly in observation group compared with control group(P<0.05).The total effective rate was higher in observation group than that in control group(P<0.05). Conclusion Carvedilol combined with revastatin can relieve the symptoms and promote levels of CTGF and Lp-PLA2 in patients with hypertension complicated by coronary atherosclerosis.

关 键 词：卡维地洛 瑞伐他汀 结缔组织生长因子 脂蛋白相关磷脂酶A2 

分 类 号：R544.1[医药卫生—心血管疾病]