天然多糖在眼部药物递送中的研究进展  

Research progress of natural polysaccharides in ocular drug delivery

作　　者：林洁 李维[2] 李敏[1] 韩晓琳 宋雨[2] 汪丹[2] 刘瑛[2] 李红[3] 邹亮[2] LIN Jie;LI Wei;LI Min;HAN Xiaolin;SONG Yu;WANG Dan;LIU Ying;LI Hong;ZOU Liang(Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学,西南特色中药资源国家重点实验室,成都611137 [2]成都大学,成都610106 [3]成都大学附属医院,成都610081

出　　处：《中国中医眼科杂志》2023年第3期264-268,共5页China Journal of Chinese Ophthalmology

基　　金：国家自然科学基金项目(82274372);四川省自然科学基金青年基金项目(2023NSFSC1785);四川省科技计划重点研发项目(2020YFN0152);药食同源植物资源开发四川省高校重点实验室开放基金(10Y201706)。

摘　　要：眼睛具有独特的解剖学和生理学屏障,眼部给药受给药屏障和泪液清除机制影响,生物利用度极低。因此,研究人员需要开发新的眼部递药制剂,以提高药物生物利用度,改善眼病治疗效果。天然多糖具有良好的增粘性和生物粘附性,可延长药物的滞留时间,易于进行修饰,已被报道应用于眼部药物的递送。本文对来源于动物、植物及微生物的天然多糖及其衍生物进行综述,发现天然多糖已被研究者用于制备不同的药物制剂用来治疗眼部疾病,但人体眼睛的情况较动物模型更为复杂。目前,关于眼组织中降解酶表达情况的相关研究还不够充分,多糖在体内的生物降解情况很难评估。因此,天然多糖在被批准用于临床之前,仍需要进行长期和深入的毒理测试和安全性评价。The eye has a unique anatomical and physiological barrier,and its drug delivery is affected by the drug delivery barrier and tear clearance mechanism,which leads to extremely low bioavailability.Therefore,researchers need to develop new ocular drug delivery preparations to improve the drug bioavailability and the treatment effect of eye diseases.Natural polysaccharide has been reported to be used in the delivery of ocular drugs due to its good tackiness and bioadhesiveness,which can prolong the retention time of drugs and is easy to modify.In this paper,natural polysaccharides and their derivatives from animals,plants and microorganisms are reviewed.It is found that natural polysaccharides have been used by researchers to prepare different pharmaceutical preparations to treat eye diseases,but the situation of human eyes is more complex than animal models.At present,the relevant research on the expression of degrading enzymes in eye tissue is not sufficient,and the biodegradation of polysaccharides in vivo is difficult to evaluate.Therefore,natural polysaccharides still need to undergo long-term and in-depth toxicological tests and safety evaluation before clinical use.

关 键 词：天然多糖 眼部药物递送系统 药物制剂 

分 类 号：R944[医药卫生—药剂学]