探讨婴幼儿血管瘤口服普萘洛尔和外敷噻吗洛尔治疗后的复发因素  

To explore the Recurrence Factors of Infant Hemangioma after Oral Propranolol and External Application of Timolol

作　　者：尤丽吐孜•许合热提 周胜 于婧婷 杨雅淇 陈静 Youlituzi Xuhereti;ZHOU Sheng;YU Jingting;YANG Yaqi;CHEN Jing(Urumqi First People's Hospital(Children's Hospital),Urumqi 830001,China)

机构地区：[1]乌鲁木齐市第一人民医院(儿童医院),新疆乌鲁木齐830001

出　　处：《中国医药指南》2023年第6期1-5,共5页Guide of China Medicine

基　　金：乌鲁木齐市卫健委科技计划项目,项目名称:新疆血管瘤患儿停β受体阻滞剂后复发因素研究,项目编号:202146。

摘　　要：目的 探讨婴幼儿血管瘤口服普萘洛尔和外敷噻吗洛尔治疗后的复发因素。方法 选取2020年6至2021年6月120例婴幼儿血管瘤患儿作为对照组,对其使用口服普萘洛尔和外敷噻吗洛尔治疗后的复发因素进行总结分析,并制定相应预防复发对策;另选取2021年7月至2022年7月120例婴幼儿血管瘤患儿作为观察组,对其采用口服普萘洛尔和外敷噻吗洛尔治疗,并实施预防复发对策。最后对两组治疗效果和复发情况进行对比。结果 对照组120例患儿中,经口服普萘洛尔和外敷噻吗洛尔治疗后的复发率为9(7.50%),导致复发的因素有女性患儿、起始治疗年龄≤16周、深部型与混合型血管瘤、非节段型血管瘤、治疗时间≤6个月,且差异均有统计学意义(P <0.05);观察组120例患儿采用口服普萘洛尔和外敷噻吗洛尔治疗,并实施预防复发对策后,其治疗后血清指标、血流动力学指标、不良反应发生率、复发情况均优于对照组,差异均有统计学意义(P <0.05)。结论 口服普萘洛尔和外敷噻吗洛尔治疗婴幼儿血管具有一定疗效,但女性患儿、起始治疗年龄≤16周、深部型与混合型血管瘤患儿、非节段型血管瘤患儿、治疗时间≤6个月患儿更易复发。因此,在婴幼儿血管瘤患儿口服普萘洛尔和外敷噻吗洛尔治疗期间采用相应预防复发措施,可有效降低其血清水平,改善其血流动力学指标,降低不良反应风险,减少其复发。Objective To investigate the recurrence factors of infant hemangioma after oral propranolol and external application of timolol.Methods One hundred and twenty cases of infant hemangioma in from June 2020 to June 2021 were selected as the control group. The recurrence factors after the treatment with oral propranolol and external application of timolol were summarized and analyzed, and the corresponding prevention countermeasures were formulated;In addition, 120 infants with hemangioma from July 2021 to July 2022 were selected as the observation group,who were treated with oral propranolol and external application of timolol, and the recurrence prevention strategy was implemented. Finally, the therapeutic effect and recurrence of the two groups were compared. Results Among the 120 children in the control group, the recurrence rate after oral propranolol and external application of timolol was 9(7.50%). The factors leading to recurrence were female children, age of starting treatment≤16 weeks, deep and mixed hemangiomas, non segmental hemangiomas, and treatment time≤6 months, and the difference was statistically significant(P<0.05). After 120 children in the observation group were treated with oral propranolol and external application of timolol,and the relapse prevention strategy was implemented, their serum indicators, hemodynamic indicators, adverse reaction rate, and relapse were better than those in the control group after treatment, and the difference was statistically significant(P<0.05). Conclusion Oral propranolol and external application of timolol are effective in the treatment of infant blood vessels, but female children, children with initial treatment age≤16 weeks,children with deep and mixed hemangioma, children with non segmental hemangioma, and children with treatment time≤6 months are more likely to relapse. Therefore, during the treatment of infant hemangioma with oral propranolol and external application of timolol, corresponding preventive measures can effectively reduce their serum lev

关 键 词：婴幼儿血管瘤 普萘洛尔 噻吗洛尔 复发因素 

分 类 号：R725.4[医药卫生—儿科]