临床联用拉贝洛尔与硫酸镁治疗妊高征对患者妊娠结局的影响分析  

Analysis of the Effect of Clinical Combined Use of Labetalol and Magnesium Sulfate in the Treatment of Pregnancy-induced Hypertension on the Outcome of Pregnancy

作　　者：齐春杰 QI Chunjie(Department of Obstetrics and Gynecology,Panshan County People's Hospital,Panshan 124107,China)

机构地区：[1]辽宁省盘山县人民医院妇产科,辽宁盘山124107

出　　处：《中国医药指南》2023年第6期102-104,共3页Guide of China Medicine

摘　　要：目的 探讨分析临床联用拉贝洛尔与硫酸镁治疗妊高征对患者妊娠结局的影响。方法 选取我院2018年10月至2019年10月收治的98例妊高征患者,随机分为对照组和研究组,给予对照组患者硫酸镁治疗,给予研究组患者拉贝洛尔与硫酸镁联合治疗,比较分析两组患者治疗效果。结果 在给予两组患者不同治疗干预措施后,研究组患者治疗总有效率为97.96%,对照组患者治疗总有效率为83.67%,两组患者比较显著差异(P <0.05);在给予两组患者2周治疗后,研究组患者收缩压为(113.38±7.39)mm Hg,舒张压为(73.65±5.18)mm Hg。对照组患者分别为(125.27±8.09)mm Hg、(85.97±5.48)mmHg。研究组患者血压控制效果明显高于对照组(P <0.05);研究组患者子痫发生率、胎盘早剥率、产后出血率、新生儿窒息率均明显优于对照组(P <0.05);两组患者在不良反应发生率上无显著差异(P> 0.05)。结论 给予妊高征患者拉贝洛尔与硫酸镁联合治疗具有显著效果,能够降低患者血压水平,维护母婴安全,治疗安全性比较高,值得推广应用。Objective To analyze the effect of clinical treatment of PIH with labetalol and magnesium sulfate on pregnancy outcome. Methods Ninetyeight patients with PIH admitted to our hospital from October 2018 to October 2019 were randomly divided into control group and study group. The patients in the control group were treated with magnesium sulfate, and the patients in the study group were treated with labetalol and magnesium sulfate.The therapeutic effects of the two groups were compared and analyzed. Results The total effective rate of the study group and the control group was 97.96% and 83.67% respectively after the treatment of the two groups(P<0.05). After two weeks of treatment, the systolic blood pressure and diastolic blood pressure of the study group were(113.38±7.39) mm Hg and(73.65±5.18) mm Hg respectively, the patients in the control group were(125.27±8.09) mm Hg and(85.97±5.48) mm Hg respectively. The control effect of blood pressure in the study group was significantly higher than that in the control group(P<0.05). The incidence of eclampsia, placental abruption, postpartum hemorrhage and neonatal asphyxia in the study group were significantly lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion The combination therapy of labetalol and magnesium sulfate has significant effect on PIH. It can reduce the blood pressure level of PIH patients, maintain the safety of mother and infant, and the safety of treatment is relatively high. It is worth popularizing and applying.

关 键 词：拉贝洛尔 硫酸镁 联合治疗 妊高征 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]