痹痛消丸联合体外冲击波治疗膝骨关节炎伴骨髓水肿  

Bitongxiao Pill Combined with Extracorporeal Shock Wave in Treating Knee Osteoarthritis with Bone Marrow Edema

作　　者：董晓坤 沈锦涛[2] 王上增[2] DONG Xiaokun;SHEN Jintao;WANG Shangzeng(Graduate School of Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The Second Affiliated Hospital of Henan University of Chinese Medicine/Henan Provincial Hospital of Chinese Medicine,Zhengzhou Henan China 450002)

机构地区：[1]河南中医药大学研究生院,河南郑州450046 [2]河南中医药大学第二附属医院/河南省中医院,河南郑州450002

出　　处：《中医学报》2023年第3期633-637,共5页Acta Chinese Medicine

基　　金：河南省自然科学基金面上项目(222300420486);国家中医临床研究基地科研专项课题项目(2021JDZX2039)。

摘　　要：目的:观察痹痛消丸联合体外冲击波治疗肝肾亏虚型膝骨关节炎伴骨髓水肿的临床疗效,并评价其安全性。方法:选取48例膝骨关节炎合并骨髓水肿患者随机分为观察组和对照组各24例。观察组给予痹痛消丸,每次6 g,每日3次,口服;对照组给予依托考昔片,每次1片,每日1次,口服;两组均联合体外冲击波,均治疗4周。比较两组患者治疗前后骨髓水肿(bone marrow edema,BME)积分、视觉模拟量表(visual analogue scale,VAS)评分及西安大略和麦克马斯特大学骨关节炎指数(western ontario and McMaster university osteoarthritis index,WOMAC)评分。结果:①治疗后,两组患者VAS评分均有所下降;观察组VAS评分为(2.96±1.16)分,低于同期对照组(P<0.05)。②治疗后,两组患者WOMAC评分均显著降低;观察组WOMAC评分为(85.71±10.13)分,低于同期对照组(P<0.05)。③治疗后,两组患者BME积分均显著降低;观察组BME积分为(5.13±1.57)分,低于同期对照组(P<0.05)。结论:痹痛消丸联合体外冲击波治疗膝骨关节炎伴骨髓水肿临床疗效显著,能明显缓解关节炎症,改善关节功能,缓解疼痛并减轻水肿状况。Objective:To observe the clinical efficacy of Bitongxiao Pill combined with extracorporeal shock wave in the treatment of knee osteoarthritis with bone marrow edema due to liver and kidney deficiency,and to evaluate its safety.Methods:48 patients with knee osteoarthritis and bone marrow edema were randomly divided into observation group and control group with 24 cases each.The observation group was given Bitongxiao Pill,6g each time,3 times a day,orally;The control group was given etocoxib tablets,one tablet each time,once a day,orally;Both groups were treated with extracorporeal shock wave for 4 weeks.The scores of bone marrow edema(BME),visual analogue scale(VAS),and Western ontarion and McMaster University Osteoarthritis index(WOMAC)were compared between the two groups before and after treatment.Results:①After treatment,the VAS score of patients in both groups decreased;The VAS score of the observation group was(2.96±1.16),lower than that of the control group at the same time(P<0.05).②After treatment,the WOMAC score of patients in both groups decreased significantly;The WOMAC score of the observation group was(85.71±10.13),lower than that of the control group at the same time(P<0.05).③After treatment,the BME score of patients in both groups decreased significantly;The BME score of the observation group was(5.13±1.57)points,lower than that of the control group at the same time(P<0.05).Conclusion:Bitongxiao Pill combined with extracorporeal shock wave has a significant clinical effect on knee osteoarthritis with bone marrow edema,which can significantly relieve joint inflammation,improve joint function,relieve pain and reduce edema.

关 键 词：膝骨关节炎 骨髓水肿 痹痛消丸 体外冲击波 依托考昔片 关节功能 

分 类 号：R274.984.3[医药卫生—中西医结合]