补肾养髓法针灸治疗血管性痴呆肾精亏虚证  

Treatment of Vascular Dementia with Kidney Essence Deficiency Syndrome by Acupuncture and Moxibustion Method of Tonifying Kidney and Nourishing Marrow

作　　者：刘雪娇 程芳[2] LIU Xuejiao;CHENG Fang(Henan Veteran Cadre Rehabilitation Hospital,Zhengzhou Henan China 450008;The Third School of Clinical Medicine Affiliated to Henan University of Chinese Medicine,Zhengzhou Henan China 450008)

机构地区：[1]河南省老干部康复医院,河南郑州450008 [2]河南中医药大学第三临床医学院,河南郑州450008

出　　处：《中医学报》2023年第3期644-648,共5页Acta Chinese Medicine

基　　金：河南省中医药拔尖人才项目{豫卫中医函[2021]15号}。

摘　　要：目的:观察补肾养髓法针灸治疗血管性痴呆肾精亏虚证的临床疗效。方法:将74例血管性痴呆肾精亏虚证患者按照随机数字表法分为对照组和研究组。对照组给予盐酸多奈哌齐片,研究组在对照组治疗基础上给予补肾养髓法针灸。两组均连续治疗4周,治疗后比较两组临床痴呆评定量表(Clinicaldementiarating, CDR)评分,内皮素1、血管紧张素Ⅱ水平,平均血流速度,搏动指数,收缩期峰值流速及临床疗效。结果:治疗后,两组患者痴呆程度均显著降低,且研究组的CDR评分[(6.15±1.80)分]低于对照组[(7.91±2.06)分],差异有统计学意义(P<0.05)。治疗后,两组患者内皮素1、血管紧张素Ⅱ水平显著降低(P<0.05);研究组患者内皮素1[(126.34±20.11) ng·L^(-1)]、血管紧张素Ⅱ[(63.67±12.76)μg·L^(-1)]水平低于同期对照组[(151.67±24.80) ng·L^(-1)和(77.25±15.19)μg·L^(-1)],差异有统计学意义(P<0.05)。两组患者治疗后的平均血流速度、收缩期峰值流速明显高于治疗前,搏动指数明显低于治疗前(P<0.05);研究组治疗后的血流速度[(37.95±7.30) cm·s^(-1)]、收缩期峰值流速[(49.23±5.68) cm·s^(-1)]高于同期对照组[(31.14±6.25) cm·s^(-1)和(45.40±5.02) cm·s^(-1)],搏动指数(0.75±0.14)低于同期对照组(0.93±0.18),差异均有统计学意义(P<0.05)。研究组有效率(94.59%)明显高于同期对照组(78.38%),差异有统计学意义(P<0.05)。结论:补肾养髓法针灸可提高血管性痴呆肾精亏虚证的疗效,可降低痴呆程度,提高血流动力学,改善血管内皮功能。Objective: To observe the clinical effect of Kidney nourishing and marrow nourishing acupuncture on vascular dementia with Kidney Essence deficiency syndrome.Methods: 74 cases of vascular dementia with kidney essence deficiency syndrome were randomly divided into control group and study group.The control group was given Donepezil Hydrochloride tablets, and the study group was given acupuncture and moxibustion with the method of tonifying the Kidney and nourishing the marrow on the basis of the treatment of the control group.The two groups were treated continuously for 4 weeks.After treatment, the clinical dementia rating scale(CDR) scores, endothelin 1,angiotensin II levels, average blood flow velocity, pulsatility index, peak systolic flow velocity and clinical efficacy of the two groups were compared.Results: After treatment, the degree of dementia in the two groups was significantly reduced, and the CDR score of the study group [(6.15±1.80) points] was lower than that of the control group [(7.91±2.06) points, the difference was statistically significant(P<0.05).After treatment, the levels of endothelin 1 and angiotensin Ⅱ in the two groups were significantly decreased(P<0.05);The levels of endothelin 1 [(126.34±20.11) ng·L^(-1)] and angiotensin Ⅱ [(63.67±12.76) μg·L^(-1)] in patients in the study group were lower than those in the control group [(151.67±24.80) ng·L^(-1)and(77.25±15.19) μg·L^(-1)] at the same time(P<0.05).After treatment, the mean blood flow velocity, peak systolic velocity and pulsatile index of the two groups were significantly higher than those before treatment(P<0.05);After treatment, the mean blood flow velocity [(37.95±7.30) cm·s^(-1)] and peak systolic velocity [(49.23±5.68) cm·s^(-1)] in the study group were higher than those in the control group [(31.14±6.25) cm·s^(-1)and(45.40±5.02) cm·s^(-1)],and the pulsation index(0.75±0.14) were lower than those in the control group(0.93±0.18),with significant differences(P<0.05).The effective rate of the study group(94.5

关 键 词：血管性痴呆 肾精亏虚证 补肾养髓法 针灸 痴呆程度 血管内皮功能 血流动力学 

分 类 号：R246.6[医药卫生—针灸推拿学]