苯硼酸响应的增强型海藻酸钠载药微囊的制备与性能  

Preparation and properties of glucose-responsive drug-loaded calcium alginate microcapsules

作　　者：林敏婕 程修文 杨云聪 章明豪 蔡玉荣[1] LIN Minjie;CHENG Xiuwen;YANG Yuncong;ZHANG Minghao;CAI Yurong(School of Materials Science&Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China)

机构地区：[1]浙江理工大学材料科学与工程学院,杭州310018

出　　处：《浙江理工大学学报（自然科学版）》2023年第2期228-236,共9页Journal of Zhejiang Sci-Tech University(Natural Sciences)

基　　金：浙江省国际科技合作项目-双边产业联合研发计划项目(2022C04027)。

摘　　要：以海藻酸钠为壳材,透明质酸钠为囊材,苯硼酸接枝的丝素蛋白纳米晶须为壳层增强相,采用同轴静电纺丝技术制备具有葡萄糖响应性的增强型海藻酸钠/透明质酸钠载药微囊,并对微囊的形貌结构、稳定性、葡萄糖响应性及细胞毒性进行分析。结果表明:采用同轴静电纺丝技术可成功制备具有核壳结构的海藻酸钠/透明质酸钠微囊,添加丝素蛋白纳米晶须可有效提高微囊的稳定性和药物包封率;丝素蛋白纳米晶须的添加量为1.0 mg/mL时,微囊的稳定性最佳,药物负载量达32.56%,药物缓释时间可长达24 h,该微囊具有灵敏的葡萄糖响应性和良好的生物相容性,是一种具有较好应用潜能的糖尿病药物载体。The enhanced sodium alginate/sodium hyaluronate microcapsules were prepared by coaxial electrospinning with sodium alginate as shell materials, sodium hyaluronate as the core material and silk fibroin nanowhiskers grafted by phenylboronic acid as the shell reinforcement phase. The morphology, stability, glucose responsiveness and cytotoxicity of the microcapsules were studied. The results show that the core-shell structured sodium alginate/sodium hyaluronate microcapsules can be successfully prepared by coaxial electrospinning, and the addition of silk fibroin nanowhiskers can effectively improve the stability and drug encapsulation rate of the microcapsules. When the dosage of silk fibroin nanowhiskers is 1.0 mg/mL, the stability of the microcapsules is the best, the drug loading efficiency reaches 32.56%, and the drug sustained release time can be prolonged to 24 h. As the microcapsules are sensitive to glucose and have good biocompatibility, they are a promising drug carrier for diabetes drugs.

关 键 词：丝素蛋白纳米纤维晶须 苯硼酸 葡萄糖响应 海藻酸钠水凝胶 药物缓释 

分 类 号：TB34[一般工业技术—材料科学与工程]