非小细胞肺癌患者术后症状负担和中医症状群调查  

Investigation on Postoperative Symptom Burden and Traditional Chinese Medicine Symptom Clusters of Patients with Non-Small Cell Lung Cancer

作　　者：韩宝瑾 刘铸 周慧灵 吴晓月 任似梦 林洪生[1] 刘杰[1] HAN Baojin;LIU Zhu;ZHOU Huiling;WU Xiaoyue;REN Simeng;LIN Hongsheng;LIU Jie(Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Qingdao Fuwai Cardiovascular Disease Hospital,Qingdao 266034,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029 [3]上海中医药大学,上海201203 [4]青岛阜外心血管病医院,山东青岛266034

出　　处：《山东中医杂志》2023年第3期244-249,共6页Shandong Journal of Traditional Chinese Medicine

基　　金：中医药行业科研专项(编号:201307006)。

摘　　要：目的:探讨非小细胞肺癌患者术后症状负担和中医症状群分布特点。方法:采用安德森症状评估量表对中国中医科学院广安门医院2020年7月至2022年6月门诊及住院的非小细胞肺癌术后非辅助治疗阶段患者进行调查。通过描述性统计和探索性因子分析探讨非小细胞肺癌患者术后症状负担和中医症状群分布特点。结果:共纳入非小细胞肺癌术后患者165例,发生率居前5位的中重度症状(≥4分)为疲乏(52%)、气短(51%)、睡眠不安(49%)、口干(39%)、咳嗽(39%);75%的患者存在2个或2个以上中重度症状(≥4分)共表达;探索性因子分析得出肺系症状群(咳嗽-咳痰-气短)、气虚兼证症状群(麻木-胸闷-疲乏-口干-疼痛-嗜睡-便秘)、情志内伤症状群(悲伤-苦恼-睡眠不安-健忘-胃口差)。结论:非小细胞肺癌术后患者中重度症状负担发生率较高,主要呈现三类症状群,影响中医症状群的因素及其与中医证候之间的关系值得进一步研究。Objective:To explore the distribution characteristics of postoperative symptom burden and traditional Chinese medicine(TCM) symptom clusters of patients with non-small cell lung cancer(NSCLC). Methods:From July 2020 to June 2022,in Guang’anmen Hospital,China Academy of Chinese Medical Sciences,the patients with NSCLC who had received operation treatment and were not treating with adjuvant therapy were investigated by the M. D. Anderson Symptom Inventory(MDASI). Descriptive statistics and exploratory factor analysis were performed to explore the distribution characteristics of symptom burden and TCM symptom clusters. Results:A total of 165 patients with NSCLC who had received operation treatment were included. In terms of incidence,the top five moderate to severe symptoms(≥4 points) were fatigue(52%),shortness of breath(51%),disturbed sleep(49%),dry mouth(39%),and cough(39%). Among the included patients,75% had coexistence phenomenon of two or more than two moderate to severe symptoms. The exploratory factor analysis revealed three major symptom clusters,including pulmonary system symptom cluster(cough-expectoration-shortness of breath),qi deficiency syndrome symptom cluster(numbness-chest tightness-fatigue-dry mouth-pain-somnolence-constipation),and emotional injury symptom cluster(sadness-distressed-disturbed sleep-forgetfulness-loss of appetite). Conclusions:In the patients with NSCLC who had received operation treatment,the incidence of moderate to severe symptoms burden is high,and there are three symptom clusters. The factors that can influence the TCM symptom clusters and the relationship between these factors and TCM syndromes are worthy of further study.

关 键 词：非小细胞肺癌 术后 症状负担 中医症状群 证候 

分 类 号：R273[医药卫生—中西医结合]