依折麦布联合他汀类药物对冠心病患者血脂代谢的影响  

Effect of ezetimibe combined with statins on lipid metabolism in patients with coronary heart disease

作　　者：桑喜梅[1] SANG Ximei(Department of CCU,Zhaoqing First People′s Hospital,Guangdong Province,Zhaoqing 526000,China)

机构地区：[1]广东省肇庆市第一人民医院CCU,526000

出　　处：《临床合理用药杂志》2023年第1期9-11,15,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 观察依折麦布联合他汀类药物对冠心病患者血脂代谢的影响。方法 选取2019年6月—2020年12月广东省肇庆市第一人民医院收治的冠心病患者100例,采用随机数字表法分为观察组和对照组,各50例。2组患者均予以降血压、降血糖及抗血小板聚集治疗。对照组采用他汀类药物治疗,观察组采用依折麦布联合他汀类药物治疗,2组均连续用药6个月。比较2组患者的临床疗效,治疗前后心功能、血脂、氧化应激指标及不良反应。结果 观察组患者的治疗总有效率为96.00%,高于对照组的84.00%,差异有统计学意义(χ^(2)=4.000,P=0.045)。治疗6个月后,2组患者左室收缩末期容积及左室舒张末期容积均明显降低,左室射血分数均明显升高,且观察组降低/升高更明显,差异均有统计学意义(P<0.01);2组患者三酰甘油、总胆固醇、低密度脂蛋白水平均显著降低,高密度脂蛋白水平显著升高,且观察组降低/升高更明显,差异均有统计学意义(P<0.01);2组患者血清过氧化物酶、丙二醇均明显降低,超氧化物歧化酶水平均明显升高,且观察组降低/升高更明显,差异均有统计学意义(P<0.01)。对照组与观察组患者的不良反应总发生率比较差异无统计学意义(8.00%vs. 6.00%,χ^(2)=0.154,P=0.695)。结论 依折麦布联合他汀类药物治疗冠心病的疗效较好,可有效改善患者的心功能和血脂水平,且安全性高,可进一步推广和应用。Objective To observe the effect of ezetimibe combined with statins on lipid metabolism in patients with coronary heart disease. Methods A total of 100 patients with coronary heart disease admitted to Zhaoqing First People′s Hospital of Guangdong Province from June 2019 to December 2020 were selected, and divided into observation group and control group by random number table method, with 50 cases in each group. Both groups were treated with hypotensive, hypoglycemic and antiplatelet aggregation therapy. The control group was treated with statins, and the observation group was treated with ezetimibe combined with statins, two groups were treated continuously for 6 months. The clinical efficacy, cardiac function, blood lipids, oxidative stress indexes and adverse reactions before and after treatment were compared between the two groups. Results The total effective rate of the observation group was 96.00%, which was higher than 84.00% of the control group, and the difference was statistically significant(χ^(2)=4.000,P=0.045).After 6 months of treatment, the left ventricular end-systolic volume and left ventricular end-diastolic volume of the two groups were significantly decreased, and the left ventricular ejection fraction were significantly increased, and the decrease/increase were more obvious in the observation group, and the differences were statistically significant(P<0.01). The levels of triglyceride, total cholesterol and low-density lipoprotein in the two groups were significantly decreased, while the levels of high-density lipoprotein were significantly increased, and the decrease/increase were more obvious in the observation group, and the differences were statistically significant(P<0.01). The levels of serum peroxidase and propylene glycol in the two groups were significantly decreased, and the levels of superoxide dismutase were significantly increased, and the decrease/increase in the observation group were more obvious, and the differences were statistically significant(P<0.01). There was no signi

关 键 词：冠心病 依折麦布 他汀类药物 临床疗效 血脂代谢 

分 类 号：R541.4[医药卫生—心血管疾病]