醒脑静注射液对颅脑损伤患者炎性因子的影响  

Effect of Xingnaojing injection on inflammatory factors in patients with craniocerebral injury

作　　者：魏明 WEI Ming(Department of Neurosurgery,Chibi General Hospital,Hubei Province,Chibi 437300,China)

机构地区：[1]湖北省赤壁市人民医院神经外科,437300

出　　处：《临床合理用药杂志》2023年第2期5-7,16,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 观察醒脑静注射液对颅脑损伤患者炎性因子的影响。方法 回顾性选取2018年8月—2019年8月湖北省赤壁市人民医院收治的颅脑损伤患者104例,按照治疗方案不同分为观察组和对照组,各52例。对照组患者进行常规治疗,观察组在对照组基础上外加醒脑静注射液治疗。采用格拉斯哥结局量表(GOS)评价2组治疗效果,比较2组治疗前后血清炎性因子[白介素-8(IL-8)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]、血液流变学指标[纤维蛋白原(Fib)、红细胞压积(Het)、微循环滞留时间(MST)、红细胞流动系数TK值]变化,并比较2组不良反应情况。结果 观察组患者治疗总显效率为76.92%,高于对照组的44.23%(χ^(2)=11.636,P=0.001);治疗1个月后,2组血清IL-8、IL-1β、TNF-α水平均较治疗前降低,且观察组低于对照组(P<0.05或P<0.01);2组Fib、MST较治疗前明显下降(P<0.01),TK值较治疗前明显升高(P<0.01),且观察组Fib、MST水平显著低于对照组,TK值明显高于对照组(P均<0.01),但2组Het治疗前后比较差异均无统计学意义(P>0.05);2组不良反应总发生率比较差异无统计学意义(26.92%vs. 34.62%,χ^(2)=0.722,P=0.395)。结论 醒脑静注射液对颅脑损伤患者有良好的协同作用,其机制可能与缓解炎性反应有关;应用后能有效降低患者颅脑损伤后的1L-8、1L-1β、TNF-α水平,减轻患者的炎性反应,临床疗效好,安全性高。Objective To explore the effect of Xingnaojing injection on inflammatory factors in patients with craniocerebral injury. Methods A total of 104 patients with craniocerebral injury who were admitted to Chibi General Hospital from August 2018 to August 2019 were retrospectively selected and divided into an observation group and a control group according to different treatment plans, with 52 cases in each. The patients in the control group were given conventional treatment, while the observation group were treated with Xingnaojing injection on the basis of the treatment of the control group. The Glasgow outcome scale(GOS) was used to evaluate the treatment effect of the two groups. The changes of serum inflammatory factors[interleukin-8(IL-8), interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α)] and hemorheology indexes[fibrinogen(Fib), hematocrit(Het), microcirculation retention time(MST), red blood cell flow coefficient TK value] were compared between the two groups before and after treatment. Comparison of the occurrence of adverse reactions between the two groups. Results The total effective rate of treatment in the observation group was 76.92%, which was higher than 44.23% in the control group(χ^(2)=11.636, P=0.001). After 1 month of treatment, the levels of serum IL-8, IL-1β and TNF-α in both groups were lower than those before treatment, and the observation group was lower than the control group(P<0.05 or P<0.01);In two groups, Fib and MST were significantly decreased(P<0.01), and TK was significantly increased(P<0.01), and the levels of Fib and MST in the observation group were significantly lower than those in the control group, and TK was significantly higher than that in the control group(all P<0.01), but there was no significant difference between the two groups before and after Het treatment(P>0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(26.92% vs. 34.62%, χ^(2)=0.722, P=0.395). Conclusion Xingnaojing injection has a good synergi

关 键 词：颅脑损伤 醒脑静注射液 干预试验 炎性因子 预后恢复 对照分析 

分 类 号：R651.15[医药卫生—外科学]