辛伐他汀联合温针灸配伍中药茶饮治疗冠心病合并高脂血症的临床疗效  

Clinical effect of simvastatin combined with warm acupuncture and traditional Chinese medicine tea in the treatment of coronary heart disease with hyperlipidemia

作　　者：林舒鸿 陈嘉源 LIN Shuhong;CHEN Jiayuan(Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital,Fuzhou 350003,China)

机构地区：[1]福建中医药大学附属康复医院,福建省康复技术重点实验室,福建省福州市350003

出　　处：《临床合理用药杂志》2023年第3期5-7,11,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 观察辛伐他汀联合温针灸配伍中药茶饮治疗冠心病合并高脂血症的临床疗效。方法 选取福建中医药大学附属康复医院接受诊治的冠心病合并高脂血症患者96例,选取时间为2019年3月—2020年12月,随机分为西医组和中西医组,各48例。西医组予以辛伐他汀,中西医组在西医组基础上予以温针灸配伍中药茶饮。2组均用药4个月。比较2组治疗前后高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、左心室收缩分数(LVSF)、中医证候积分,不良反应。结果 治疗4个月后,西医组和中西医组LDL-C、TC、TG较同组治疗前降低,HDL-C较同组治疗前升高,且中西医组LDL-C、TC、TG较西医组低,HDL-C较西医组高(P<0.05)。治疗后,西医组和中西医组LVESD、LVEDD较同组治疗前缩小,LVEF、LVSF较同组治疗前升高,中医证候积分较同组治疗前降低,且中西医组LVESD、LVEDD较西医组小,LVEF、LVSF较西医组高,中医证候积分较西医组低(P<0.05)。中西医组不良反应总发生率低于西医组(P<0.05)。结论 辛伐他汀联合温针灸配伍中药茶饮治疗冠心病合并高脂血症的临床疗效优于单一辛伐他汀治疗,其可更有效地降低血脂水平,改善心功能和临床症状,且安全性较高。Objective To observe clinical effect of simvastatin combined with warm acupuncture and traditional Chinese medicine tea in the treatment of coronary heart disease with hyperlipidemia. Methods A total of 96 cases of patients with coronary heart disease with hyperlipidemia were selected from March 2019 to December 2020 in Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital, which were randomly divided into group A and group B, with 48 cases in each group. The group A was given simvastatin, and the group B was given warm acupuncture combined with traditional Chinese medicine tea on the basis of the group A. Both groups were breated for 4 months. HDL-C, LDL-C, TG, TC, LVESD, LVEDD, LVEF, LVSF and TCM syndrome scores before and after treatment were compared between the two groups, and the incidence of adverse reactions were observed. Results After treatment, LDL-C, TC, TG of the group A and the group B were lower than those of the same group before treatment, and HDL-C was higher than that of the same group before treatment, and LDL-C, TC, TG of the group B were lower than those of the group A, and HDL-C was higher than that of the group A(P<0.05). After treatment, the LVESD and LVEDD of the group A and the group B were smaller than those of the same group before treatment, and the LVEF, LVSF were higher than those of the same group before breatment, and TCM syndrome scores was lower than that of the same group before treatment, and LVESD and LVEDD of the group B were smaller than those of the group A, and the LVEF, LVSF were higher than those of group A, and TCM syndrome scores was lower than that of the group A(P<0.05). The total incidence of adverse reactions in the group B was lower than that in the group A(P<0.05). Conclusion The clinical efficacy of simvastatin combined with warm acupuncture and traditional Chinese medicine tea in the treatment of coronary heart disease with hyperlipidemia is better than that of simvastatin alone, it can more effectively reduce blood lipid levels

关 键 词：冠心病 高脂血症 辛伐他汀 温针灸 中药茶饮 

分 类 号：R541.4[医药卫生—心血管疾病] R589.2[医药卫生—内科学]