硝石化生汤在促进复杂性肛瘘术后创面愈合中的应用效果  

Application effect of saltpeter decoction in promoting wound healing after complicated anal fistula

作　　者：罗琪明 刘宁 何炜[3] 李欣 LUO Qiming;LIU Ning;HE Wei;LI Xin(Department of Proctology,Shehong Hospital of Traditional Chinese Medicine,Shehong 629200,China;Depar tment of Proctology,Suining Central Hospital of Sichuan Province,Suining 629000,C hina;Department of Proctology,Suining Hospital of Traditio nal Chinese Medicine,Suining 629000,China)

机构地区：[1]四川省射洪市中医院肛肠科,四川射洪629200 [2]四川省遂宁市中心医院肛肠科,四川遂宁629000 [3]四川省遂宁市中医院肛肠科,四川遂宁629000

出　　处：《当代医药论丛》2023年第5期144-147,共4页

基　　金：四川省中医药管理局科学技术研究专项;编号:2020LC0167。

摘　　要：目的:探讨硝石化生汤在促进复杂性肛瘘术后创面愈合中的应用效果。方法:选取2020年12月至2021年12月射洪市中医院、遂宁市中心医院、遂宁市中医院收治的复杂性肛瘘患者360例,随机分为对照组和观察组各180例。两组均行肛瘘放射状多切口加浮线引流术,对照组术后给予高锰酸钾溶液(1∶5000)熏洗,观察组使用硝石化生汤熏洗坐浴。比较两组的创面愈合情况及治疗前后血清细胞生长因子与炎症因子的水平。结果:观察组术后7 d、14 d的创面分泌物渗出、创缘水肿评分均低于对照组(P<0.05)。观察组术后7 d、14 d的疼痛视觉模拟量表(VAS)评分均低于对照组(P<0.05)。观察组术后7 d、14 d的创面愈合率均高于对照组(P<0.05)。观察组的创面愈合时间短于对照组(P<0.05)。术后14 d,两组的血管内皮细胞生长因子(VEGF)、表皮生长因子(EGF)水平均较术后1 d明显升高,且观察组均高于对照组(P<0.05);肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平均明显降低,且观察组均低于对照组(P<0.05)。结论:硝石化生汤熏洗坐浴能够促进复杂性肛瘘术后创面愈合,改善创面水肿,减轻疼痛。Objective:To investigate the application effect of saltpeter Huashang decoction in promoting wound healing after complicated anal fistula surgery.Methods:A total of 360 patients with complicated anal fistula admitted to Shehong Hospital of Traditional Chinese Medicine,Suining Central Hospital and Suining Hospital of Traditional Chinese Medicine from December 2020 to April 2021 were selected and randomly divided into control group and observation group,180 patients in each group.Anal fistula radiating multiple incisions plus floating line drainage were performed in both groups.The control group was given fumigation with potassium permanganate solution(1:5000)after surgery,and the observation group was given fumigation sit-bath with saltpeter chemical soup.Wound healing and serum levels of growth factor and inflammatory factor before and after treatment were compared between the two groups.Results:The score of wound secretion exudation and edge edema in the observation group were lower than those in the control group on day 7 and 14 after surgery(P<0.05).Visual analog Scale(VAS)scores of the observation group were lower than those of the control group at 7 and 14 days after surgery(P<0.05).The wound healing rate of the observation group was higher than that of the control group at 7 and 14 days after surgery(P<0.05).The wound healing time of observation group was shorter than that of control group(P<0.05).The levels of vascular endothelial cell growth factor(VEGF)and epidermal growth factor(EGF)in 2 groups were significantly increased 14 days after surgery compared with 1 day after surgery,and the observation group were higher than the control group(P<0.05).The levels of tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were significantly decreased,and the observation group were lower than the control group(P<0.05).Conclusion:Saltpeter decoction fumigation sit-bath can promote wound healing,improve wound edema and relieve pain after complicated anal fistula surgery.

关 键 词：硝石化生汤 肛瘘 创面 炎症因子 愈合 

分 类 号：R657.16[医药卫生—外科学]