多环芳烃暴露致红细胞损伤生物暴露限值基准剂量分析  

Determination of biological exposure limit of damage in red blood cells caused by exposure to polycyclic aromatic hydrocarbons using benchmark dose method in general population

作　　者：王青青[1] 崔靖 彭雯洁 张婷 袁苗 庞琳 周小林[2,3] 余红梅 WANG Qingqing;CUI Jing;PENG Wenjie;ZHANG Ting;YUAN Miao;PANG Lin;ZHOU Xiaolin;YU Hongmei(Department of Health Statistics,School of Public Health,Shanxi Medical University,Taiyuan,Shanxi 030001,China;China Institute for Radiation Protection,Taiyuan,Shanxi 030006,China;State Environmental Protection Key Laboratory of Radiation Environment and Health,Taiyuan,Shanxi 030006,China;Shanxi Provincial Key Laboratory of Major Diseases Risk Assessment,Taiyuan,Shanxi 030001,China)

机构地区：[1]山西医科大学公共卫生学院卫生统计教研室,山西太原030001 [2]中国辐射防护研究院,山西太原030006 [3]国家环境保护辐射环境与健康重点实验室,山西太原030006 [4]重大疾病风险评估山西省重点实验室,山西太原030001

出　　处：《公共卫生与预防医学》2023年第2期16-20,共5页Journal of Public Health and Preventive Medicine

基　　金：生态环境部重点地区环境与健康调查、监测和风险评估(21111011101EHSM);国家环境保护辐射环境与健康重点实验室平台开放基金(YP21020203)。

摘　　要：目的应用基准剂量法探讨非职业人群长期多环芳烃暴露血液系统损害的生物接触限值,为进一步完善多环芳烃健康损害效应评估提供相关参考依据。方法选择山西省某焦化厂下风向常住成年居民为研究对象,采用历史对照法以基线收集的信息为对照组。尿中多环芳烃代谢物为暴露生物标志物,红细胞指标异常率为效应指标,运用贝叶斯基准剂量软件计算研究对象尿中多环芳烃代谢物的基准剂量及其下限。结果研究对象尿中多环芳烃代谢物以萘和芴为主。2-OHFlu和1-OHPhe末年检测浓度均高于基线检测浓度(P<0.05)。随着暴露年限延长,末年红细胞异常率高于基线红细胞异常率(P均<0.05)。此外,红细胞异常率随5种尿中多环芳烃代谢物浓度的增加而升高,卡方趋势性检验有意义(P均<0.05)。5种尿中多环芳烃代谢物的基准剂量值分别为0.67μmol/mol Cr、0.82μmol/mol Cr、1.40μmol/mol Cr、0.78μmol/mol Cr,其中有烧烤饮食习惯的人群2-OHNaP的基准剂量值为0.23μmol/mol Cr,无烧烤饮食习惯的人群为1.44μmol/mol Cr。结论尿中多环芳烃代谢浓度与红细胞指标损伤之间存在剂量-反应关系且长年多环芳烃暴露可导致人体血液系统损伤。提示可制定针对性的公共卫生干预措施以减少一般人群对多环芳烃的接触。Objective To explore the biological exposure limit of blood system damage caused by long-term exposure to polycyclic aromatic hydrocarbons(PAHs)in non-occupational population by using the benchmark dose method,and to provide relevant reference for further improving the assessment of PAHs-induced health damage effects.Methods Adult residents living in downwind direction of a coke-oven plant in Shanxi Province were selected as the research subjects,and the information collected from baseline was used as the control.The metabolites of PAHs in urine were used as exposure biomarker,and the abnormal rate of red blood cell index was used as response biomarker.The relationship between urinary OH-PAHs and the erythrocyte damage rate was analyzed,and the benchmark dose(BMD)and the lower confidence limitation for the benchmark dose(BMDL)were calculated using Bayesian dose-optimizing software.Results The urinary PAH metabolites were mainly naphthalene and fluorene.The detection concentrations of 2-OHFlu and 1-OHPhe in the final year were higher than those in the baseline(P<0.05).With the increase of exposure years,the abnormal rate of red blood cells in the final year was higher than that in the baseline(P<0.05).In addition,the abnormal rate of red blood cells increased with the increase of the concentrations of five metabolites of PAHs in urine,and the chi-square trend test was significant(P<0.05).The benchmark dose(BMD)of OH-PAHs was 0.67μmol/mol Cr,0.82μmol/mol Cr,1.40μmol/mol Cr and 0.78μmol/mol Cr,respectively.The BMD of 2-OHNap in people with barbecue diet habits was 0.23μmol/mol Cr.The BMD of 2-OHNap in people without barbecue diet habits was 1.44μmol/mol Cr.Conclusion There is a dose-response relationship between the concentration of PAHs metabolites in urine and the damage of red blood cells.Long-term exposure to PAHs can lead to hematological damage.It is suggested that targeted public health interventions should be formulated to reduce the exposure of the general population to PAHs.

关 键 词：多环芳烃 长期暴露 血液系统损伤 基准剂量 生物暴露限值 

分 类 号：R115[医药卫生—公共卫生与预防医学]