疑似职业性苯中毒案例分析及GC-MS的应用  

Case study of occupational benzene poisoning and application of GC-MS

作　　者：刘保峰[1] 刘蒙蒙 秦汝男 夏义平[1] 李旭东 曾强[1] LIU Baofeng;LIU Mengmeng;QIN Runan;XIA Yiping;LI Xudong;ZENG Qiang(Institute for Occupational Health,Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China)

机构地区：[1]天津市疾病预防控制中心职业健康研究所,天津300011

出　　处：《公共卫生与预防医学》2023年第2期36-39,共4页Journal of Public Health and Preventive Medicine

基　　金：天津市卫生健康科技项目(ZC20084);天津市医学重点学科(专科)建设项目(2021)。

摘　　要：目的对加油站行业15例疑似职业性苯中毒诊断案例进行分析,并探讨气质联用(GC-MS)技术在职业病诊断中的应用。方法采用流行病学方法对15名加油站作业人员职业病诊断情况进行描述分析,应用GC-MS技术对加油站职业危害因素进行定性筛查。结果15名劳动者均有超过1年的加油、卸油职业史。临床表现均符合《职业性苯中毒的诊断》慢性苯中毒特征。但因缺少职业性苯接触的依据,未能诊断为职业性慢性苯中毒。GC-MS技术对某加油站工作场所职业危害因素进行筛查,发现存在苯、正戊烷、正己烷等。结论建议对加油站作业人员开展职业病诊断时,应用GC-MS技术对苯等危害因素进行定性筛查,准确识别作业场所中有毒物质,为职业病诊断提供可靠依据。Objective To analyze the diagnosis cases of occupational benzene poisoning in gas station industry,and to explore the application of GC-MS technology in occupational disease diagnosis.Methods The epidemiological method was used to describe and analyze the occupational disease diagnosis of 15 gas station workers,and qualitative screening of occupational hazard factors was performed by GC-MS.Results All the 15 workers had more than one year′s occupation history of oil refueling and unloading.The clinical manifestations were consistent with the characteristics of chronic benzene poisoning in diagnosis of occupational benzene poisoning.However,due to lack of evidence of occupational exposure to benzene and incomplete diagnostic data,occupational chronic benzene poisoning was not diagnosed.GC-MS technology was used to screen the occupational hazard factors in the gas station workplace,and benzene,n-pentane,n-hexane and so on were found.Conclusion GC-MS is recommended for qualitative screening of organic solvents such as benzene when diagnosing occupational diseases for gas station workers,so as to accurately identify occupational hazard factors in workplaces and provide reliable basis for diagnosis of occupational diseases.

关 键 词：苯中毒 GC-MS 职业病诊断 加油站 接触史 

分 类 号：R181[医药卫生—流行病学]