肥胖青少年血尿酸水平特点及其与代谢指标的相关性研究  

Characteristics of blood uric acid level and its correlation with metabolic indexes in obese adolescents

作　　者：李自栋 贺亚楠 钱帅伟 李晓敏 徐霞[1,2] 李春艳 LI Zidong;HE Yanan;QIAN Shuaiwei;LI Xiaomin;XU Xia;LI Chunyan(School of Sports Medicine,Wuhan Sports University,Wuhan,Hubei 430079,China;Hubei Key Laboratory of Sport Training and Monitoring,Wuhan,Hubei 430079,China;Wuhan Sports University Hospital,Wuhan,Hubei 430079,China)

机构地区：[1]武汉体育学院运动医学院,湖北武汉430079 [2]运动训练监控湖北省重点实验室,湖北武汉430070 [3]武汉体育学院医院,湖北武汉430070

出　　处：《公共卫生与预防医学》2023年第2期87-91,共5页Journal of Public Health and Preventive Medicine

基　　金：国家自然科学基金项目(81971661);“十四五”湖北省优势特色学科群;武汉体育学院中青年科研团队(21KT11)。

摘　　要：目的此文旨在探究减肥训练营肥胖青少年血尿酸水平特点及其与钙磷水平、糖脂代谢指标的关联性。方法选取12~18岁的357名肥胖青少年作为研究对象,以135名体重正常的青少年作为对照,测定并分析掌握受试者身体形态及血尿酸特点,进一步从肥胖青少年中选取59名受试者进行血钙、血磷及糖脂代谢指标测试,以分析血尿酸与钙磷代谢及糖脂代谢指标的相关性。结果肥胖青少年的血尿酸水平平均为(527.12±122.94)μmol/L,其中男生为(566.58±122.51)μmol/L,女生为(468.35±97.79)μmol/L,均显著高于对照组(男生P<0.001,女生P<0.05),且男生高于女生(P<0.01);肥胖青少年尿酸偏高者占比73.39%。肥胖青少年的HOMA-IR为5.79±3.04;血尿酸水平与血钙、总胆固醇、低密度脂蛋白胆固醇水平显著性相关(P<0.05);性别、低密度脂蛋白胆固醇为血尿酸的主要影响因素(P<0.05)。结论肥胖青少年血尿酸水平偏高,机体存在低钙高磷状态,同时肥胖青少年胰岛素抵抗发生率较高,肥胖青少年血尿酸水平与机体钙磷代谢及糖脂代谢具有一定相关性,提示临床上监控低密度脂蛋白等脂代谢指标对于防治高尿酸血症具有一定的参考价值。Objective To explore the characteristics of blood uric acid levels and its correlation with calcium and phosphorus levels,and glucose and lipid metabolism in obese adolescents in weight-loss training camps.Methods In this study,357 obese adolescents aged 12-18 were selected as the research subjects,and 135 normal-weight adolescents were selected as the controls.The body shape and blood uric acid characteristics of the subjects were measured and analyzed.Further,59 subjects were selected from the obese adolescents for blood calcium,blood phosphorus and glucose and lipid metabolism index tests to analyze the correlation between blood uric acid level and calcium,phosphorus,and glucose and lipid metabolism indicators.Results The average blood uric acid level of obese adolescents was(527.12±122.94)μmol/L,(566.58±122.51)μmol/L for boys,and(468.35±97.79)μmol/L for girls.The blood uric acid level of the obesity group was significantly higher than that of the control group(P<0.001 for boys,P<0.05 for girls),and it was higher in boys than in girls(P<0.01).Obese adolescents with high uric acid accounted for 73.39%.The HOMA-IR of obese adolescents was 5.79±3.04.The blood uric acid level was significantly correlated with blood calcium,total cholesterol,and low-density lipoprotein cholesterol(P<0.05).Gender and low-density lipoprotein cholesterol were the main influencing factors of blood uric acid(P<0.05).Conclusion Obese adolescents have high blood uric acid levels,low calcium and high phosphorus in the body,and a higher incidence of insulin resistance.There exists a positive correlation between the blood uric acid level and the body′s calcium and phosphorus metabolism and glucose and lipid metabolism in obese adolescents.Clinical monitoring of lipid metabolism indicators such as low-density lipoprotein has certain reference value for the prevention and treatment of hyperuricemia.

关 键 词：肥胖青少年 血尿酸 钙磷代谢 糖脂代谢 

分 类 号：R181[医药卫生—流行病学]