老年肺心病患者肾损伤影响因素的单中心病例对照研究  

Single center case-control study on influencing factors of renal injury in elderly patients with cor pulmonale

作　　者：张晓花 苗婷 湛守清 ZHANG Xiaohua;MIAO Ting;ZHAN Shouqing(Department of Cardiology and Critical Medicine,Qinghai Cardiovascular and Cerebrovascular Disease Hospital,Xining,Qinghai 810000,China)

机构地区：[1]青海省心脑血管病专科医院心脏重症医学科,青海西宁810000

出　　处：《公共卫生与预防医学》2023年第2期92-95,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的探讨老年肺心病患者肾损伤的影响因素,为预防肺心病患者出现肾损伤提供信息参考。方法研究收集2019年6月至2020年12月期间青海省心脑血管病专科医院接诊的60岁以上老年肺心病患者309例纳入研究,根据患者是否并发肾损伤分为肺心病肾损伤组(病例组)和肺心病无肾损伤组(对照组),收集两组患者基本信息以及既往潜在影响肾损伤的影响因素,经单因素分析以及回归模型分析老年肺心病患者肾损伤的影响因素。结果单因素分析病例组比对照组男性、年龄>80岁、具有吸烟史、糖尿病家族史、并发感染、并发糖尿病及左心室射血分数(LVEF)<56.00%比例更高,且病例组比对照组舒张压水平、收缩压水和血红蛋白水平更高,差别均有统计学意义(P<0.05);将上述单因素分析结果带入多回归模型,最终多元回归分析提示年龄>80岁(OR=3.142),吸烟史(OR=2.115),并发感染(OR=4.263),以及收缩压超标(OR=2.279)4个因素为潜在增加肾损伤发生风险的危险因素,均有统计学意义(P<0.05)。结论老年肺心病患者年龄超过80岁、具有吸烟史和血压异常者,以及并发感染者发生肾损伤风险增高,值得临床关注并予以相关预防措施,以改善患者预后。Objective To explore the influencing factors of renal injury in elderly patients with cor pulmonale,and to provide information for the prevention of renal injury in patients with cor pulmonale.Methods A total of 309 elderly patients with cor pulmonale over 60 years old treated in our hospital from June 2019 to December 2020 were included in the study.According to the patients with renal injury,they were divided into cor pulmonale renal injury group(case group)and cor pulmonale non renal injury group(control group).The basic information of the two groups and the influencing factors of potential renal injury in the past were collected,The influencing factors of renal injury in elderly patients with cor pulmonale were analyzed by univariate analysis and regression model.Results The single factor analysis of the case group was higher than that of the control group,with a male age of 80 years,smoking history,family history of diabetes,concurrent infection,diabetes mellitus and left ventricular ejection fraction(LVEF)<56.00%ratio.The difference between the case group and the control group was higher than that of the control group(P<0.05).The above univariate analysis results were brought into the multiple regression model.The final multiple regression analysis showed that age>80 years old(OR=3.142),smoking history(OR=2.115),concurrent infection(OR=4.263),and excessive systolic blood pressure(OR=2.279)were the risk factors potentially increasing the risk of renal injury,which were statistically significant(P<0.05).Conclusion Elderly patients with cor pulmonale over 80 years old,with smoking history and abnormal blood pressure,as well as those complicated with infection,have an increased risk of renal injury.It is worthy of clinical attention and relevant preventive measures to improve the prognosis of patients.

关 键 词：老年人群 肺心病 肾损伤 

分 类 号：R181[医药卫生—流行病学]