2019—2020年湖南航天医院抗菌药物不良反应分析  

Analysis of adverse reactions of antibiotics in Hunan Aerospace Hospital from 2019 to 2020

作　　者：魏云 冯桂梅[1] 王曙光[1] 于勇文 WEI Yun;FENG Guimei;WANG Shuguang;YU Yongwen(Department of Pharmacy,Hunan Aerospace Hospital,Hunan Province,Changsha 410205,China)

机构地区：[1]湖南航天医院药剂科,长沙市410205

出　　处：《临床合理用药杂志》2023年第4期8-11,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：航天医科课题(2020YK15)。

摘　　要：目的分析湖南航天医院抗菌药物不良反应的发生特点和规律及其影响因素,为临床安全合理使用抗菌药物提供可靠的依据。方法2019年1月1日—2020年12月31日湖南航天医院上报国家不良反应监测中心的不良反应报告170例,对患者的一般资料、药物品种、给药途径、临床表现及严重不良反应进行分析。结果170例报告中,女性患者(88例,占比51.76%)多于男性患者(82例,占比48.24%),>60岁患者(50例,占比29.41%)最多;不良反应涉及药品以注射用哌拉西林钠他唑巴坦钠数量最多(44例,占比25.88%);青霉素类抗菌药物引发的不良反应占比最高(54例,占比31.76%),其中注射用哌拉西林钠他唑巴坦钠最多;静脉为最主要的给药途径(169例,占比99.41%);不良反应以皮肤及其附件损害最常见(119例,70.00%);一般的不良反应最多(163例,95.88%),严重者5例(2.94%);严重的不良反应主要涉及血象下降,最终的转归均为好转。结论医院应进一步加强抗菌药物的管理,严密监测抗菌药物不良反应,规范合理使用抗菌药物,尽量避免或减少不良反应的发生,确保患者用药安全。Objective To analyze the occurrence characteristics and regularity of adverse reactions of antibiotics in Hunan Aerospace Hospital,analyze the influencing factors of adverse reactions of antibiotics,and provide a reliable basis for the safe and rational use of antibiotics in clinical practice.Methods Collected 170 adverse reaction reports from Hunan Aerospace Hospital to the National Adverse Reaction Monitoring Center from January 1,2019 to December 31,2020,and analyzed the general information of patients,drug varieties,route of administration,clinical manifestations and serious adverse reactions.Results Among the 170 reports,female patients(88 cases,accounting for 51.76%)were more than male patients(82 cases,accounting for 48.24%),and patients>60 years old(50 cases,accounting for 29.41%)were the most;The number of adverse reactions involving drugs was piperacillin sodium and tazobactam sodium for injection(44 cases,accounting for 25.88%);Adverse reactions caused by penicillin antibiotics accounted for the highest proportion(54 cases,accounting for 31.76%),among which piperacillin sodium and tazobactam sodium for injection were the most;Intravenous was the main route of administration(169 cases,accounting for 99.41%);The most common adverse reactions were skin and its accessories damage(119 cases,70.00%);The reported adverse reactions were the most common adverse reactions(163 cases,95.88%),and 5 serious cases(2.94%);Serious adverse reactions mainly involved the decrease of blood count,and the final outcome was improved.Conclusion The hospital should further strengthen the management of antibacterial drugs,closely monitor the adverse reactions of antibacterial drugs,standardize the rational use of antibacterial drugs,try to avoid or reduce the occurrence of adverse reactions,and ensure the safety of patients′medication.

关 键 词：抗菌药物 不良反应 合理用药 

分 类 号：R978[医药卫生—药品]