肾衰康方对慢性肾衰竭患者的临床效果及肾功能保护作用分析  

An analysis of clinical efficacy and renal function protection of Shenshuaikang prescription on chronic renal failure

作　　者：罗丽 郑剑琴 LUO Li;ZHENG Jianqin

机构地区：[1]广东祈福医院,广东广州511495

出　　处：《中医临床研究》2022年第36期34-36,共3页Clinical Journal Of Chinese Medicine

基　　金：广东省中医药局科研项目(20202149)。

摘　　要：目的:分析肾衰康方对慢性肾衰竭(Chronic Renal Failure,CRF)患者的临床效果及肾功能的保护作用。方法:选定广东祈福医院2020年1-12月住院和门诊治疗的50例CRF患者,根据随机数字表法分组,参照组25例患者予以常规治疗,试验组25例患者在常规治疗基础上予以肾衰康方治疗,均在治疗21 d后评价两组治疗效果,比较两组临床疗效、中医证候积分(腰膝酸软、恶心呕吐、食少纳呆、倦怠乏力积分)、肾功能指标[血清肌酐(Serum Creatinine,Scr)、胱抑素-C(Cystatin-C,Cys-C)、血尿素氮(Blood Urea Nitrogen,BUN)、24 h尿蛋白]、血清炎性因子指标[超敏C反应蛋白(Hypersensitive C-reactive Protein,hsCRP)、白细胞介素-6(Interleukin-6,IL-6)]。结果:试验组临床总有效率高于参照组(P<0.05);治疗前,两组患者的中医证候积分、肾功能指标与血清炎性因子指标比较,差异无统计学意义(P>0.05),试验组治疗后腰膝酸软、恶心呕吐、食少纳呆、倦怠乏力积分均低于参照组,差异均存在统计学意义(P<0.05)。试验组治疗后血清Scr、Cys-C、BUN、24 h尿蛋白、hs-CRP、IL-6因子均低于参照组,差异均存在统计学意义(P<0.05)。结论:肾衰康方可有效缓解CRF患者的病情,积极提升患者的临床疗效,最大程度上改善肾功能指标,缓解炎症反应,防止疾病进展,临床疗效显著、确切,值得临床进一步借鉴与推广。Objective:To analyze the clinical efficacy and renal function protection of Shenshuaikang prescription(肾衰康方)in patients with chronic renal failure(CRF).Methods:A total of 50 patients with CRF who received inpatient and outpatient treatment in Clifford Hospital of Guangdong from January 2020 to December 2020 were selected and divided into groups according to the random number table method.A total of 25 patients in the control group were given routine treatment,and 25 patients in the test group were given Shenshuaikang prescription on the basis of routine treatment.The therapeutic effect in the two groups was evaluated after 21 days of treatment,and the clinical efficacy,TCM syndrome score(lumbar and knee weakness,nausea and vomiting,inappetence,and fatigue scores),renal function indexes(serum Scr,Cys-C,BUN,24 h urine protein)and serum inflammatory factor indexes(hs-CRP,and IL-6)were compared between the two groups.Results:The total clinical efficiency in the test group was higher than that in the control group(P<0.05).Before treatment,there were no statistically significant differences in TCM syndrome scores,renal function indexes and serum inflammatory factor indexes between the two groups(P>0.05),and scores of lumbar and knee weakness,nausea and vomiting,inappetence,and fatigue after treatment in the test group were lower than those in the control group(P<0.05).After treatment,serum Scr,Cys-C,BUN,24 h urine protein,hs-CRP and IL-6 factors in the test group were lower than those in the control group(P<0.05).Conclusion:Shenshuaikang prescription can effectively alleviate the condition of patients with chronic renal failure,actively improve the clinical efficacy of patients,maximize the improvement of renal function indicators,alleviate inflammatory reactions,and prevent disease progression.The clinical efficacy is significant and accurate,which is worthy of further reference and promotion in clinical practice.

关 键 词：肾衰康方 慢性肾衰竭 临床疗效 肾功能 

分 类 号：R256.5[医药卫生—中医内科学]