基于射频通信的实验大鼠生理参数监测系统  

Experimental rat physiological parameter monitoring system based on radio frequency communication

作　　者：孔嘉铭 张晗 马坤龙[3] 张本金[4] 杨刚[2] KONG Jiaming;ZHANG Han;MA Kunlong;ZHANG Benjin;YANG Gang(Department of Automation,School of Electrical Engineering,Sichuan University,Chengdu 610065,China;Department of Medical information and Instruments,School of Biomedical Engineering,Sichuan University,Chengdu 610065,China;Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China;Pediatrics of Dazhou Central Hospital,Dazhou 635099,China)

机构地区：[1]四川大学电气工程学院自动化系,四川成都610065 [2]四川大学生物医学工程学院医学信息及仪器系,四川成都610065 [3]重庆医科大学附属永川医院,重庆402160 [4]达州市中心医院,四川达州635099

出　　处：《传感器与微系统》2023年第3期103-107,共5页Transducer and Microsystem Technologies

基　　金：重庆市基础与前沿研究项目(CSTC2018JCYJAX0744);川大—达州校地合作项目(2020CDDZ—23)。

摘　　要：为了解决生物医学研究中实验大鼠无创生理参数监测的问题,设计了一种实验大鼠可穿戴生理监测系统。系统选择STM32作为主控芯片实现光电容积脉搏波(PPG)、心电图(ECG)的采集,并利用无线射频(RF)通信将生理信号传输到上位机。最后SD大鼠活体实验表明:系统采集的ECG波形特征与标准ECG仪采集的信号一致,在95%置信区间(±1.96 SD)内,该系统心率(HR)均值误差为-0.5 bpm;系统采集的大鼠腹部、耳朵和尾部PPG峰度较高。因此,该系统可以无创、实时地监测自由活动大鼠的ECG、HR和PPG等生理指标。In order to solve the problem of noninvasive physiological parameter monitoring of experimental rats in biomedical research, a wearable physiological monitoring system of experimental rats is designed.In this system, STM32 is selected as the master control chip to collect photoplethysmography(PPG)and electro-cardiogram(ECG),and the physiological signal is transmitted to the upper computer by wireless radio frequency(RF)communication.Finally, the in vivo experiment of SD rats show that the characteristics of ECG waveform collected by the system are consistent with those collected by standard ECG.The mean error of heart rate(HR)in 95 % confidence interval(±1.96 SD)is-0.5 bpm.The kurtosis of PPG in abdomen, ear and tail of rats collected by this system is high.Therefore, the system can monitor the physiological indexes such as ECG、HR and PPG in free-moving rats in non-invasive and real-time.

关 键 词：SD大鼠 可穿戴 生理参数 无创 无线射频通信 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] R318.6[自动化与计算机技术—控制科学与工程]