新生儿肠道病毒脑炎12例临床特点及转归分析  

CLINICAL FEATURES AND OUTCOME OF NEONATES WITH ENTEROVIRUS ENCEPHALITIS:AN ANALYSIS OF 12 CASES

作　　者：锡洪敏[1] 邵惠[1] 高芳 姜红[1] 李向红[1] XI Hongmin;SHAO Hui;GAO Fang;JIANG Hong;LI Xianghong(Department of Neonatology,The Affiliated Hospital of Qingdao University,Qingdao 266555,China)

机构地区：[1]青岛大学附属医院新生儿科,山东青岛266555 [2]青岛市老年病医院院感科

出　　处：《精准医学杂志》2023年第1期22-24,共3页Journal of Precision Medicine

基　　金：青岛大学附属医院“临床医学+X”科研项目(QDFY+2021013)。

摘　　要：目的了解新生儿肠道病毒脑炎的临床特点,提高对该疾病的早期识别,以预防感染爆发。方法选取2019年6月—2022年6月于我院住院的肠道病毒脑炎新生儿12例,对患儿的临床特点及实验室检查结果进行分析,总结治疗重点及评估预后。结果12例患儿中早产儿7例,临床呈非特异性败血症样表现,炎症指标正常或轻度升高。所有患儿脑脊液肠道病毒核酸检测阳性。所有患儿均进行标准隔离,静注人免疫球蛋白及对症支持治疗,预后良好。结论新生儿肠道病毒脑炎临床表现不典型,需要早期识别,实施针对性感染防控策略。Objective To investigate the clinical features of neonates with enterovirus encephalitis,and to prevent the outbreak of enterovirus infection by improving the early identification of this disease.Methods A total of 12 neonates with enterovirus encephalitis who were admitted to our hospital from June 2019 to June 2022 were enrolled and analyzed in terms of clinical features and laboratory examination.The key points of treatment were summarized,and their prognosis was assessed.Results Among the 12 neonates,7 were preterm infants,with the clinical manifestations of nonspecific sepsis-like symptoms and normal or mildly elevated inflammatory markers.All neonates tested positive for enterovirus nucleic acid in cerebrospinal fluid.All neonates were given standard isolation,intravenous injection of human immunoglobulin,and symptomatic supportive treatment and achieved a good prognosis after treatment.Conclusion Neonates with enterovirus encephalitis often have atypical clinical manifestations and thus require early identification and targeted strategies for the prevention and control of infection.

关 键 词：肠道病毒感染 脑炎 病毒性 婴儿 新生 体征和症状 治疗学 

分 类 号：R725.123[医药卫生—儿科]