儿童难治性喉源性咳嗽中药复方治疗效果多参数研究  

Multi-parameter study of Chinese herbal compound forchildren with refractory laryngeal cough

作　　者：吕永川 李雪 刘丹丹[1] 娄丹 LV Yongchuan;LI Xue;LIU Dandan(Shijiazhuang People’s Hospital,Hebei,Shijiazhuang 050011,China)

机构地区：[1]河北省石家庄市人民医院,050011

出　　处：《河北医药》2023年第1期30-34,共5页Hebei Medical Journal

基　　金：河北省中医药管理局科研计划项目(编号:2019457)。

摘　　要：目的探讨中药复方治疗儿童喉源性咳嗽(又称咽源性咳嗽)的临床疗效并进行多参数检验。方法选择2020年6月至2021年6月就诊的难治性喉源性咳嗽儿童患者66例,随机分为试验组和对照组,每组33例。试验组采用中药复方(自拟利咽止咳汤)治疗,对照组患儿给予小儿肺热咳喘口服液治疗,均治疗14 d,采用中医证候症状体征积分量表(1 d、7 d、14 d)评价治疗效果;莱斯特咳嗽量表(LCQ-MC)(1 d、14 d)评估生活质量;监测血清中肿瘤坏子因子-α(TNF-α)、白介素-6(IL-6)、高敏C-反应蛋白(hs-CRP)治疗前后的变化情况(1 d、14 d)。电子喉镜评估治疗前后咽喉镜像变化以及活检查看病理演变。结果中医证候症状积分各参数情况:治疗1 d试验组各参数(主要症状、次要症状、体征)均无统计学差异(P>0.05);治疗后(7 d、14 d)试验组患者的各参数均较1 d改善,且14 d较7 d各参数差异有统计学意义(P<0.01);对照组治疗7 d与治疗1 d淋巴滤泡无统计学差异(P>0.05);对照组其他各参数治疗前后差异显著(P<0.01);治疗后(7 d、14 d)试验组各参数7 d淋巴滤泡项除外均优于对照组,(P<0.05)。2组患者中医证候症状体征总积分比较:治疗1 d 2组参数总积分无统计学差异(P>0.05);治疗7 d、14 d 2组患者的各项参数均较1 d改善,且14 d较7 d各参数差异有统计意义(P<0.01)。2组患者愈显率比较:治疗14 d试验组的愈显率为87.88%明显高于对照组的45.45%(P<0.01)。2组患者1 d、14 d LCQ-MC评分情况比较:治疗1 d 2组LCQ-MC各项(心理、生理及社会)评分均无统计学差异(P>0.05);治疗14 d 2组患者较治疗1 d各项评分均改善,且试验组明显优于对照组,差异有统计学意义(P<0.05)血清炎性因子水平比较:与治疗1 d相比,2组患者治疗14 d血清中TNF-α、IL-6、hsCRP含量均明显降低,差异有统计学意义(P<0.01),且治疗14 d试验组比对照组降幅更明显,差异有统计学意义(P<0.01)。结论中药�Objective To explore the clinical efficacy of Chinese herbal compound in the treatment of children’s laryngeal cough(pharyngeal cough) and to conduct multi-parametertest.Methods A total of 66 children with refractory laryngeal cough were randomly assigned 1∶1 to self-made Liyan Cough Relief(the experimental group) or Xiaoerfeire Kechuan Oral Liquid(the control group) for 14 days. Traditional Chinese medicine(TCM) Syndrome Symptoms and Signs Score Scale(1d, 7d, 14d) was applied to evaluate the treatment efficacy. Leicester Cough Scale(LCQ-MC)(1d, 14d) was adopted to assess the quality of life and monitor changes in serum tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6) amd C-reactive protein(hs-CRP) before and after treatment(1d, 14d).Electronic laryngoscopy was adopted to assess change in the throat mirror image before and after treatment and biopsy to check the pathological evolution.Results 1-day each parameter of TCM syndromes(main symptoms, minor symptoms, and physical signs) in groups were not statistically different(P>0.05),while 7-,14-day each parameter were superior to 1-day each parameter, and statistical differences were noted between 14-day and 7-day(P<0.01). There was no statistical significance in follicular lymphoid between 7-day and 1-day(P>0.05). The differences in other parameters of the control group between before and after treatment were significant(P<0.01). Except for 7-day lymphoid follicles, the other parameters in the experimental group were better than those in the control group(P<0.05). 1-day total scores of TCM syndromes in groups were not statistically different(P>0.05),while 7-,14-day total scores were superior to 1-day total scores, and statistical differences were noted between 14-day and 7-day(P<0.01).14-day improvement rates in the experimental group were significantly higher than those in the control group((P<0.01).1-day LCQ and MC scores in groups were not statistically different(P>0.05),while 14-day LCQ and MC scores were superior to 1-day LCQ and MC scores, and whic

关 键 词：中药复方 自拟利咽止咳方 儿童咽喉炎 难治性咳嗽 多参数研究 

分 类 号：R441.5[医药卫生—诊断学]