间充质干细胞来源外泌体在骨缺损再生中的应用与进展  

Application and progress of exosomes derived from mesenchymal stem cells in bone defect regeneration

作　　者：张志伟 周楠 李孟奇 张锴[1] 李朋[1] Zhang Zhiwei;Zhou Nan;Li Mengqi;Zhang Kai;Li Peng(Department of Orthopaedic Trauma,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院创伤骨科,滨州256603

出　　处：《国际医药卫生导报》2023年第3期306-310,共5页International Medicine and Health Guidance News

基　　金：山东省自然科学基金(ZR2020QH071)。

摘　　要：外泌体是来自细胞旁分泌的一种细胞外囊泡,因其含有多种生物活性因子,在细胞间通讯、诱导细胞分化中起重要作用。间充质干细胞来源的外泌体能够影响骨组织细胞增殖、通过信号通路调控诱导成骨、减少免疫炎性反应来促进骨缺损再生。近年来,外泌体与骨缺损再生之间的关系引起研究者的注意。本文对此方面的研究进展进行综述。Exosomes are extracellular vesicles derived from paracrine cells.Because exosomes contain a variety of bioactive factors,they play an important role in cell-cell communication and inducing cell differentiation.Exosomes derived from mesenchymal stem cells can promote the bone defect regeneration by affecting the proliferation of bone tissue cells,inducing the osteogenesis through signaling pathway regulation,and reducing the immune inflammatory response.In recent years,researchers have paid more attention to the relationship between exosomes and bone defect regeneration.This paper reviews the research progress in this field.

关 键 词：骨缺损 骨再生 间充质干细胞 外泌体 

分 类 号：R683[医药卫生—骨科学]