人端粒酶逆转录酶在肿瘤转录调控机制中的研究进展  

Research progress of human telomerase reverse transcriptase in tumor transcriptional regulation mechanism

作　　者：曾平 郭鹏翔(综述) 骆横(审校) ZENG Ping;GUO Pengxiang;LUO Heng(Clinical College of Guizhou Medical University,Guiyang 550004,China;Department of Hematology,The Affiliated People′s Hospital of Guizhou Medical University;Key Laboratory of Chemistry for Natural Products,Guizhou Province and Chinese Academy of Sciences)

机构地区：[1]贵州医科大学临床医学院,贵阳550004 [2]贵州医科大学附属人民医院血液内科 [3]贵州省中国科学院天然产物化学重点实验室

出　　处：《实用肿瘤学杂志》2023年第1期68-72,共5页Practical Oncology Journal

基　　金：吴阶平医学基金会临床科研专项资助基金(编号:320.6750.2020-19-16)。

摘　　要：人端粒酶逆转录酶(human telomerase reverse transcriptase,hTERT)是调节端粒酶活性的核心及限速成分,在调节端粒长度、保持基因稳定、调控肿瘤细胞的生长发育等方面发挥着极其重要的作用。近年来,hTERT在肿瘤转录调控机制方面的研究取得了新进展,对hTERT的研究已成为端粒酶研究的热点问题。TERT启动子突变的关键因子GA结合蛋白A、新型hTERT转录调控因子及hTERT高甲基化肿瘤区的发现均可能提供新的潜在治疗靶点。本文将从启动子突变、转录调控因子及表观遗传修饰对hTERT的转录调控进行综述,旨在为hTERT相关研究和开发以hTERT为靶点的药物提供理论基础。Human telomerase reverse transcriptase(hTERT)is the core and rate-limiting component of regulating telomerase activity.It plays an important role in regulating telomere length,maintaining gene stability,and regulating the growth and development of tumor cells.At present,the research on hTERT has become a hot issue in the research of telomerase.In recent years,the study of hTERT in the transcriptional regulation mechanism of tumor transcription has been made new progress.The discovery of GA-binding protein alpha,a key factor of TERT promoter mutation,novel hTERT transcriptional regulators,and hTERT hypermethylated tumor region may provide potential new therapeutic targets.This article will review the transcriptional regulation of hTERT from promoter mutations,transcriptional regulators and epigenetic modifications,aiming to lay a theoretical foundation for hTERT-related research and the development of hTERT-targeted drugs.

关 键 词：端粒酶 人端粒酶逆转录酶 启动子突变 转录调控因子 表观遗传修饰 

分 类 号：R551.3[医药卫生—血液循环系统疾病]