血清miR-24联合动态心电图在冠心病无症状心肌缺血患者中的诊断价值  

The diagnostic value of miR-24 combined with dynamic electrocardiogram in silent myocardial ischemia patients with coronary heart disease

作　　者：郭潮[1] 张慧[1] 陈敏[1] 曾涛[2] GUO Chao;ZHANG Hui;CHEN Min;ZENG Tao(Electrocardiogram Room,Guangzhou First People's Hospital,Guangzhou 510000,China;Department of Neurology,Guangzhou First People's Hospital,Guangzhou 510000,China)

机构地区：[1]广州市第一人民医院心电图室,广东广州510000 [2]广州市第一人民医院脑内科,广东广州510000

出　　处：《西部医学》2023年第3期372-376,共5页Medical Journal of West China

基　　金：广东省科技计划项目(2018KJYZ026)。

摘　　要：目的探讨血清miR-24联合动态心电图(DCG)在冠心病无症状心肌缺血(SMI)患者中的诊断价值。方法选取我院2020年10月—2021年6月疑似SMI患者73例,所有研究对象均进行冠状动脉造影检查、DCG检查和血清miR-24检测。以冠脉造影结果为金标准,比较血清miR-24联合DCG诊断SMI患者的准确度、灵敏度和特异度;比较该检查方法对冠脉病变程度的诊断效果。结果血清miR-24联合DCG诊断SMI的灵敏度,特异度,准确度高于DCG诊断方法(P<0.05),与冠脉造影结果具有较好一致性;对于冠脉单支病变、双支病变、三支病变的检出率比较,二者联合诊断的检出率均高于血清miR-24、DCG检查方法(P<0.05)。结论血清miR-24联合DCG诊断方法对SMI患者的早期筛查具有重要的诊断价值,可在临床进一步研究和推广。Objective To explore the diagnostic value of miR-24 combined with dynamic electrocardiogram(DCG)in silent myocardial ischemia(SMI)patients with coronary heart disease.Methods A total of 73 patients with asymptomatic myocardial ischemia suspected of coronary heart disease from October 2020 to June 2021 in our hospital were selected,all of whom received underwent coronary angiography,miR-24 and DCG.Taking the results of coronary angiography as the gold standard,to compare the accuracy,sensitivity and specificity of serum mir-24 combined with DCG in the diagnosis of SMI patients,and compare the diagnostic effect of this method on the degree of coronary artery lesions.Results The sensitivity,specificity and accuracy of miR-24 combined with DCG in diagnosing SMI were significantly higher than that of DCG(P<0.05),and had excellent consistency with the results of coronary angiography;miR-24 combined with DCG were all higher than those of dynamic electrocardiogram on the detection rates of single-vessel,double-vessel and three-vessel coronary diseases(P<0.05).Conclusion The diagnostic method of serum miR-24 combined with DCG has important diagnostic value for the early screening of SMI patients,which is worthy of further study and promotion.

关 键 词：血清miR-24 动态心电图 无症状心肌缺血 冠心病 

分 类 号：R540.41[医药卫生—心血管疾病] R541.4[医药卫生—内科学]