白头翁化学成分及其药理作用研究进展  

Research Progress in Chemical Constituents and Pharmacological Effects of Pulsatilla chinensis

作　　者：苏晓悦[1,2] 徐驰 杜鑫 王震[2] 张美琦 任伟超[2] 刘秀波[3] 马伟[2] SU Xiaoyue;XU Chi;DU Xin;WANG Zhen;ZHANG Meiqi;REN Weichao;LIU Xiubo;MA Wei(The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China;Jiamusi College,Heilongjiang University of Chinese Medicine,Jiamusi 154007,China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040 [3]黑龙江中医药大学佳木斯学院,黑龙江佳木斯154007

出　　处：《中医药信息》2023年第3期76-82,共7页Information on Traditional Chinese Medicine

基　　金：国家重点研发计划课题项目(2021YFD160090);黑龙江省中医药管理局“中医药经典普及化专项课题”项目(ZYW2022-033)。

摘　　要：白头翁为临床常用中药,主治热毒血痢、阴痒带下、肛门灼热等。本文综述国内外相关文献资源,发现白头翁含有很多种化学成分,例如三萜皂苷类、三萜酸类、香豆素类、木脂素类、脂肪酸类以及小分子类等,具有非常高的药用价值和广泛的应用前景。在临床上可用于治疗肠炎、肺炎、肿瘤、流感以及肝损伤等,具有抗肿瘤、抗病毒、抗炎、抗阴道毛滴虫、抑菌杀菌、杀精、抗氧化、抗诱变、保护肝脏、增强免疫功能以及影响细胞增殖和凋亡等作用。但白头翁除三萜皂苷类以外的其他化学成分并未得到深入的研究,部分药理作用如抗氧化、杀精以及对免疫功能和细胞调控的影响等方面并未在临床上得到很好的挖掘和应用。As a commonly used Chinese medicinal in clinical practice,Pulsatilla chinensis is often used for heat-toxin dysentery,pruritus vulvae,vaginal discharge and burning pain in anus.This study reviewed related literature,and found that Pulsatilla chinensis contained a variety of chemical components,including triterpene saponins,triterpene acid,coumarin,lignans,fatty acid and small molecules.It has very high medicinal value and wide application value which can be used to treat enteritis,pneumonia,tumors,influenza and liver damage in clinic.Modern pharmacological researches have found that Pulsatilla chinensis has the effect of anti-tumor,anti-virus,anti-inflammation,anti-vaginal trichomoniasis,bacteriostat and bactericide,spermicide,anti-oxidation,anti-mutagenesis,liver protection and immune enhancement,it can also affect cell proliferation and apoptosis.However,except triterpene saponins,other ingredients have not been studied in depth,and partial pharmacological effects,such as anti-oxidation,spermicide and its effect on immune function and cellular processing have not been well explored and used in clinical practice.

关 键 词：白头翁 化学成分 药理作用 研究进展 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]