拉贝洛尔联合阿司匹林治疗子痫前期的效果及对血管内皮功能的影响  

Effect of Labetalol Combined with Aspirin in the Treatment of Preeclampsia and Its Influence on Vascular Endothelial Function

作　　者：龙园 曾艳珍 詹卫星[1] LONG Yuan;ZENG Yanzhen;ZHAN Weixing(Ganzhou People's Hospital,Jiangxi Province,Ganzhou 341000,China;不详)

机构地区：[1]江西省赣州市人民医院,江西赣州341000

出　　处：《中国医学创新》2023年第7期46-49,共4页Medical Innovation of China

基　　金：赣州市指导性科技计划项目(GZ2021ZSF214)。

摘　　要：目的:探讨拉贝洛尔联合阿司匹林治疗子痫前期的效果及对血管内皮功能的影响。方法:选取2021年8-12月赣州市人民医院收治的60例子痫前期患者,按照用药方式的不同将其分为对照组(阿司匹林)与观察组(拉贝洛尔+阿司匹林),各30例。比较血压、尿蛋白、血管内皮功能、不良反应及妊娠结局情况。结果:治疗2周,两组收缩压、舒张压、尿蛋白、内皮素(endothelin,ET-1)、一氧化氮(nitric oxide,NO)水平均优于治疗前,且观察组均优于对照组(P<0.05)。两组不良反应发生率、不良妊娠结局及剖宫产发生率比较,差异均无统计学意义(P>0.05)。结论:子痫前期予以拉贝洛尔联合阿司匹林治疗,能够有效降低患者血压、尿蛋白水平,促进血管内皮功能恢复,提高治疗安全性。Objective:To investigate the effect of Labetalol combined with Aspirin in the treatment of preeclampsia and its influence on vascular endothelial function.Method:A total of 60 preeclampsia patients admitted to Ganzhou People’s Hospital from August to December 2021 were selected,they were divided into control group(Aspirin)and observation group(Labetalol+Aspirin)according to different medication methods,with 30cases in each group.Blood pressure,urinary protein,vascular endothelial function,adverse reactions and pregnancy outcomes were compared.Result:After 2 weeks of treatment,the levels of systolic blood pressure,diastolic blood pressure,urinary protein,endothelin(ET-1)and nitric oxide(NO)in both groups were better than those before treatment,and those in the observation group were better than those in the control group(P<0.05).There were no significant difference in the incidence of adverse reactions,adverse pregnancy outcomes and cesarean section between the two groups(P>0.05).Conclusion:The treatment of preeclampsia with Labetalol combined with Aspirin is beneficial to reduce blood pressure and urinary protein levels,promote the recovery of vascular endothelial function,with high safety.

关 键 词：子痫前期 拉贝洛尔 阿司匹林 血管内皮功能 

分 类 号：R714.244[医药卫生—妇产科学]