青年急性心肌梗死发病危险因素的Meta分析  

Meta-analysis of Risk Factors for Acute Myocardial Infarction in Young Adults

作　　者：莫健姣 黄显南[1] 刘燕[1] 刘莉[1] 周柳芳[1] MO Jianjiao;HUANG Xiannan;LIU Yan;LIU Li;ZHOU Liufang(Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China;不详)

机构地区：[1]右江民族医学院附属医院,广西百色533000

出　　处：《中国医学创新》2023年第7期162-167,共6页Medical Innovation of China

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(20211684)。

摘　　要：目的:系统评价青年急性心肌梗死发生的主要危险因素,为心肌梗死预防决策提供依据。方法:检索PubMed、Embase、Web of Science、Cochrane、Library、万方数据、中国知网(CNKI)、维普网(VIP)、中国生物医学文献数据库(CBM)等,均从建库日期检索至2022年4月的所有文献,全面收集与青年急性心肌梗死发病危险因素有关的所有病例-对照研究。由2名评价员初步筛选并独立提取资料,并评价其方法学质量。对符合要求的研究,采用RevMan 5.3和Stata 14.0统计软件对提取的相关数据进行分析。结果:最终纳入7篇病例对照研究文献,病例组1061例,对照组1627例。Meta分析结果显示吸烟[OR=2.40,95%CI(1.84,3.13)]、心血管病家族史[OR=1.97,95%CI(1.53,2.55)]、高血脂[OR=1.79,95%CI(1.52,2.12)]、高血压[OR=2.17,95%CI(1.61,2.92)]、糖尿病[OR=1.99,95%CI(1.11,3.56)]与青年急性心肌梗死发病相关。结论:吸烟、心血管病家族史、高血脂、高血压、糖尿病是目前青年急性心肌梗死发病的危险因素。Objective:To systematically evaluate the main risk factors of acute myocardial infarction in young adults,and to provide evidence for preventive decision-making.Method:PubMed,Embase,Web of Science,Cochrane,Library,Wanfang Data,China National Knowledge Network(CNKI),VIP,and China Biomedical Literature Database(CBM)were searched for all literatures from the date of database establishment to April 2022,comprehensively collect all case-control studies related to risk factors for acute myocardial infarction in young adults.The data were initially screened and independently extracted by two evaluators,and the methodological quality was evaluated.For the research that meets the requirements,RevMan 5.3 and Stata 14.0 statistical software are used to analyze the extracted relevant data.Result:A total of 7 case-control studies were included,including 1061 cases in the case group and 1627 cases in the control group.The results of meta-analysis showed that smoking[OR=2.40,95%CI(1.84,3.13)],family history of cardiovascular disease[OR=1.97,95%CI(1.53,2.55)],hyperlipidemia[OR=1.79,95%CI(1.52,2.12)],hypertension[OR=2.17,95%CI(1.61,2.92)],diabetes mellitus[OR=1.99,95%CI(1.11,3.56)]were associated with acute myocardial infarction in young adults.Conclusion:Smoking,family history of cardiovascular disease,hyperlipidemia,hypertension and diabetes are risk factors for acute myocardial infarction in young adults.

关 键 词：急性心肌梗死 吸烟 高血压 高血脂 

分 类 号：R542.22[医药卫生—心血管疾病]