肠黏膜屏障改变对IgA肾病的影响  

Effect of intestinal mucosal barrier changes on IgA nephropathy

作　　者：兰馨 闫勇[2,3] 王尊松 Lan Xin;Yan Yong;Wang Zun-song(Shandong First Medical University,Jinan 250117,China;Weifang Medical University,Weifang 261053,China;Department of Nephrology,the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Shandong Institute of Nephrology,Jinan 250014,China)

机构地区：[1]山东第一医科大学,济南250117 [2]潍坊医学院,潍坊261053 [3]山东第一医科大学第一附属医院(山东省千佛山医院)肾脏病学,山东省肾脏病研究所,济南250014

出　　处：《临床肾脏病杂志》2023年第1期62-65,共4页Journal Of Clinical Nephrology

基　　金：山东第一医科大学学术提升计划(2019QL012);中华国际交流基金会肾性贫血科研基金(Z-2017-24-2037);山东省千佛山医院国家自然科学基金培育基金(QYPY2019NSFC1009)。

摘　　要：IgA肾病是目前世界范围内最常见的原发性肾小球疾病,主要表现为肾小球系膜区IgA沉积或以IgA沉积为主。越来越多的证据表明,肠黏膜屏障的改变与IgA肾病的发生、发展有着密切的关联。明确肠黏膜屏障稳态的维持以及肠黏膜屏障破坏的机制对研究IgA肾病的发生、发展及治疗有着重要作用。本文综述了肠黏膜屏障改变影响IgA肾病的机制以及重塑肠道微环境、改善肠黏膜屏障、调节肠道内免疫细胞的增殖、分化和分泌对改善和治疗IgA肾病的作用。IgA nephropathy is the most common primary glomerular disease in the world.It is mainly manifested as IgA deposition or mainly IgA deposition in glomerular mesangium.Growing evidences show that the changes of intestinal mucosal barrier are closely correlated with the occurrence and development of IgA nephropathy.Clarifying the mechanism of maintenance of intestinal mucosal barrier homeostasis and the destruction of intestinal mucosal barrier plays an important role in researches on the occurrence,development and treatment of IgA nephropathy.This review summarized the mechanism of intestinal mucosal barrier changes affecting IgA nephropathy and the effects of remodeling intestinal microenvironment,improving intestinal mucosal barrier and regulating proliferation,differentiation and secretion of immune cells in intestinal tract in improvement and treatment of IgA nephropathy.

关 键 词：IGA肾病 肠黏膜 肠道菌群 紧密连接 免疫系统 

分 类 号：R692.31[医药卫生—泌尿科学]