正交试验优选麝香化瘀醒脑颗粒水提工艺  

Optimization of Water Extraction Process of Shexiang Huayu Xingnao Granules by the Orthogonal Test

作　　者：黄江 黄锐 袁渊 蒲清荣 杨思进 白雪 杨云芳 HUANG Jiang;HUANG Rui;YUAN Yuan;PU Qingrong;YANG Sijin;BAI Xue;YANG Yunfang(The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou,Sichuan,China 646000)

机构地区：[1]西南医科大学附属中医医院,四川泸州646000

出　　处：《中国药业》2023年第6期51-54,共4页China Pharmaceuticals

基　　金：国家中医临床研究基地建设单位科研项目[西南医大中医院[2020]33号]。

摘　　要：目的 优选麝香化瘀醒脑颗粒的水提工艺。方法 以样品提取液中总蒽醌含量和干浸膏质量的综合评分为评价指标,以加水量、浸泡时间、煎煮时间、煎煮次数为考察因素,采用L_(9)(3^(4))正交试验法优选麝香化瘀醒脑颗粒的水提工艺。结果 优选的最佳水提工艺参数为加10倍量水,浸泡0.5 h,煎煮2次,每次1.0 h。结论 该水提工艺简便、可行,结果稳定,可用于麝香化瘀醒脑颗粒的提取。Objective To optimize the water extraction process of Shexiang Huayu Xingnao Granules.Methods The water extraction process of Shexiang Huayu Xingnao Granules was optimized by the L_(9)(3^(4)) orthogonal test with the comprehensive score of the total anthraquinone content in the sample extraction solution and the amount of the dry extract as the evaluation index,and with the water addition,soaking time,decocting time and decocting times as the investigation factors.Results The optimal water extraction process parameters were as follows:adding 10 times of water,soaking for 0.5 h,decocting twice,each time for 1.0 h.Conclusion The water extraction process is simple and feasible with stable results,which can be used for the extraction of Shexiang Huayu Xingnao Granules.

关 键 词：麝香化瘀醒脑颗粒 总蒽醌 干浸膏 正交试验 水提工艺 

分 类 号：R943[医药卫生—药剂学]