醒脾养儿颗粒联合多潘立酮对功能性消化不良患儿血清胃肠激素、胃蛋白酶原和炎症因子的影响  

Effects of Xingpi Yanger Granule Combined with Domperidone on Serum Gastrointestinal Hormones, Pepsinogen and Inflammatory Factors in Children with Functional Dyspepsia

作　　者：秦艳 秦海荣[1] 杜丽芳 金翠[1] 赵青[1] QIN Yan;QIN Hai-rong;DU Li-fang;JIN Cui;ZHAO Qing(Department of Digestive,Shanxi Children's Hospital,Taiyuan,Shanxi,030013,China;Department of Traditional Chinese Medicine,Shanxi Children's Hospital,Taiyuan,Shanxi,030013,China)

机构地区：[1]山西省儿童医院消化科,山西太原030013 [2]山西省儿童医院中医科,山西太原030013

出　　处：《现代生物医学进展》2022年第24期4725-4728,4733,共5页Progress in Modern Biomedicine

基　　金：中国妇幼保健协会-华润三九中医中西医结合妇幼健康专项研究基金(ZXY2020B07)。

摘　　要：目的:观察醒脾养儿颗粒联合多潘立酮对功能性消化不良(FD)患儿血清胃肠激素、胃蛋白酶原和炎症因子的影响。方法:选取2019年1月~2021年12月期间于我院就诊的FD患儿97例,随机分为对照组和研究组,例数分别为48例和49例。对照组患儿接受多潘立酮治疗,研究组患儿接受醒脾养儿颗粒联合多潘立酮治疗。对比两组疗效、临床症状缓解情况、血清胃肠激素、胃蛋白酶原、炎症因子和不良反应。结果:研究组(91.84%)的临床总有效率高于对照组(75.00%),差异有统计学意义(P<0.05)。研究组腹胀、恶心呕吐、腹痛、厌食等症状缓解时间均短于对照组(P<0.05)。研究组治疗14 d后胃泌素(GAS)、胃动素(MTL)、胃蛋白酶原I(PGI)、胃蛋白酶原II(PGII)水平高于对照组(P<0.05)。研究组治疗14 d后白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、生长抑素(SS)、白介素-6(IL-6)、C反应蛋白(CRP)水平低于对照组(P<0.05)。两组不良反应发生率组间对比无差异(P>0.05)。结论:醒脾养儿颗粒联合多潘立酮治疗FD患儿,可促进患儿症状改善,提高临床总有效率,可能与有效调节血清胃肠激素、胃蛋白酶原和炎症因子水平有关。Objective: To observe the effects of Xingpi Yanger granule combine with domperidone on serum gastrointestinal hormones, pepsinogen and inflammatory factors in children with functional dyspepsia(FD). Methods: 97 children with FD who were treated in our hospital from January 2019 to December 2021 were selected, they were randomly divided into control group and study group, the number of cases were 48 and 49 respectively. The children in the control group were treated with domperidone, the children in the study group were treated with Xingpi Yanger granule combined with domperidone. The efficacy, clinical symptom relief, serum gastrointestinal hormones, pepsinogen, inflammatory factors and adverse reactions were compared between the two groups. Results: The total clinical effective rate of the study group(91.84%) was higher than that of the control group(75.00%), and the difference was statistically significant(P<0.05). The relief time of abdominal distension, nausea and vomiting, abdominal pain and anorexia in the study group were shorter than those in the control group(P<0.05). 14 d after treatment, the levels of gastrin(GAS), motilin(MTL), pepsinogen I(PGI) and pepsinogen II(PGII) in the study group were higher than those in the control group(P<0.05). 14 d after treatment, the levels of interleukin-10(IL-10), tumor necrosis factor-α(TNF-α), somatostatin(SS), interleukin-6(IL-6) and c-reactive protein(CRP) in the study group were lower than those in the control group(P<0.05). There was no difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Xingpi Yanger granule combine with domperidone in the treatment of FD children can promote the improvement of symptoms and improve the total clinical effective rate, which may be related to the effective regulation of serum gastrointestinal hormone, pepsinogen and inflammatory factor levels.

关 键 词：醒脾养儿颗粒 多潘立酮 功能性消化不良 胃肠激素 胃蛋白酶原 炎症因子 

分 类 号：R725.7[医药卫生—儿科]