活血逐瘀汤联合单硝酸异山梨酯治疗心血瘀阻型冠心病心绞痛患者的效果  

Effects of Huoxue Zhuyu decoction combined with Isosorbide mononitrate in treatment of coronary heart disease angina pectoris of heart blood stasis

作　　者：卢志超 贾振 LU Zhichao;JIA Zhen(Emergency Department of the People No.3 Hospital of Anyang,Anyang 455000 Henan,China)

机构地区：[1]安阳市第三人民医院急诊科,河南安阳455000

出　　处：《中国民康医学》2023年第3期87-89,93,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察活血逐瘀汤联合单硝酸异山梨酯治疗心血瘀阻型冠心病心绞痛患者的效果。方法:选取2016年8月至2019年10月该院收治的134例心血瘀阻型冠心病心绞痛患者进行前瞻性研究,采用随机数字表法将其分为对照组和研究组各67例。对照组采用单硝酸异山梨酯氯化钠注射液治疗,研究组在对照组基础上联合活血逐瘀汤治疗。比较两组临床疗效、治疗前后血管内皮功能指标[一氧化氮(NO)、一氧化氮合酶(NOS)、内皮素(ET)、基质金属蛋白酶-9(MMP-9)]水平、血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平,以及不良反应发生率。结果:研究组治疗总有效率为91.04%(61/67),高于对照组的77.61%(52/67),差异有统计学意义(P<0.05);治疗后,两组血清NO、NOS水平均高于治疗前,且研究组高于对照组,两组血清ET、MMP-9水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组血清TC、TG、LDL-C水平均低于治疗前,且研究组低于对照组,两组血清HDL-C水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:活血逐瘀汤联合单硝酸异山梨酯治疗心血瘀阻型冠心病心绞痛患者可提高治疗总有效率,改善血管内皮功能指标和血脂指标水平,效果优于单纯单硝酸异山梨酯治疗。Objective:To observe effects of Huoxue Zhuyu decoction combined with Isosorbide mononitrate in treatment of coronary heart disease angina pectoris of heart blood stasis.Methods:A prospective study was conducted on 134 patients with coronary heart disease angina pectoris of heart blood stasis type admitted to the hospital from August 2016 to October 2019.They were divided into control group and study group by using the random number table method,67 cases in each group.The control group was treated with Isosorbide mononitrate and sodium chloride injection,while the study group was treated with Huoxue Zhuyu decoction on the basis of those of the control group.The clinical efficacy,the vascular endothelial function index levels[nitric oxide(NO),nitric oxide synthase(NOS),endothelin(ET),matrix metalloproteinase-9(MMP-9)],the blood lipid index levels[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 91.04%(61/67),which was higher than 77.61%(52/67)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of serum NO and NOS in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of serum ET and MMP-9 in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of serum TC,TG and LDL-C in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the serum HDL-C levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and th

关 键 词：冠心病心绞痛 心血瘀阻型 活血逐瘀汤 单硝酸异山梨酯 血管内皮功能 血脂 

分 类 号：R541.4[医药卫生—心血管疾病]