老年2型糖尿病患者衰弱的影响因素分析  

Influential Factors for Frailty in Older Patients with Type 2 Diabetes Mellitus

作　　者：佀思聪 杨伟[1] 罗鸿宇[1] 马艺欣 赵欢 Si Sicong;Yang Wei;Luo Hongyu;Ma Yixin;Zhao Huan(Department of Geriatrics,Xuanwu Hospital of Capital Medical University,Beijing 100053)

机构地区：[1]首都医科大学宣武医院老年综合科,北京100053

出　　处：《国际老年医学杂志》2023年第2期140-144,共5页International Journal of Geriatrics

基　　金：国家自然科学基金(81600927);2022年北京市医院管理中心培养计划项目(PX2022032);首都医科大学校长培养基金(PYZ201844)。

摘　　要：目的探究老年2型糖尿病患者衰弱的影响因素。方法选择2019年1~12月首都医科大学宣武医院老年综合科住院的73例老年2型糖尿病患者作为研究对象,收集其一般资料,衰弱情况通过Fried衰弱表型量表进行评价,测定糖化血红蛋白(HbA1c)、糖化白蛋白(GA)、白细胞介素6(IL-6)及同型半胱氨酸(HCY)等指标,计算GA/HbA1c。采用有序logistic回归分析老年2型糖尿病患者衰弱分级的独立影响因素。结果73例老年2型糖尿病患者的衰弱得分为1(0,2)分,无衰弱26例(35.62%),衰弱前期36例(49.32%),衰弱期11例(15.06%)。不同衰弱分级的老年2型糖尿病患者性别、年龄、病程、HCY、IL-6及GA/HbA1c比较,差异均有统计学意义(P<0.05)。有序logistic回归分析显示女性、HCY、GA/HbA1c≥3是老年2型糖尿病患者衰弱发生的独立危险因素(P<0.05)。结论老年2型糖尿病患者衰弱发生率高,应加强早期筛查,识别危险因素并对危险因素进行干预有助于减少衰弱发生。Objective To explore the influential factors for frailty in older patients with type 2 diabetes mellitus(T2DM).Methods A study was performed on 73 older patients with T2DM hospitalized in Xuanwu Hospital of Capital Medical University from January 2019 to December 2019.The general data were collected.The frailty was evaluated by Fried Frailty Phenotype(FP).The levels of glycated hemoglobin(HbA1c),glycated albumin(GA),interleukin-6(IL-6)and homocysteine(HCY)were measured.The ratio of GA/HbA1c was calculated.Ordinal logistic regression was used to analyze independent factors for frailty.Results The score of frailty in 73 older patients with T2DM was 1(0,2).There were 26 patients without frailty(35.62%),36 patients with pre-frailty(49.32%),and 11 patients with frailty(15.06%).There were significant differences in gender,age,course of disease,levels of HCY,IL-6 and GA/HbA1c ratio among patients with different frailty status(P<0.05).Ordinal logistic regression showed that female,HCY level and GA/HbA1c≥3 were independent risk factors for frailty in older patients with T2DM(P<0.05).Conclusion The incidence of frailty is high in older patients with T2DM.Early screening and intervention should be performed according to risk factors to reduce the occurrence of frailty.

关 键 词：老年2型糖尿病 衰弱 同型半胱氨酸 白细胞介素6 糖化白蛋白 糖化血红蛋白 

分 类 号：R587.1[医药卫生—内分泌]