辅酶Q10辅助治疗老年高血压合并心律失常的疗效及作用机制  

Efficacy and Mechanism of Coenzyme Q10 in the Treatment of Older Hypertensive Patients with Arrhythmia

作　　者：刘翠[1] 高翔[1] Liu Cui;Gao Xiang(Hospital of Xinjiang Production and Construction Corps,Xinjiang 830000)

机构地区：[1]新疆生产建设兵团医院,新疆830000

出　　处：《国际老年医学杂志》2023年第2期218-222,共5页International Journal of Geriatrics

基　　金：新疆维吾尔自治区自然科学基金项目(2019D01C102)。

摘　　要：目的探讨辅酶Q10辅助治疗老年高血压合并心律失常的疗效及作用机制。方法选取2019年6月~2021年2月新疆生产建设兵团医院收治的104例老年高血压合并心律失常患者作为研究对象进行前瞻性研究,根据随机数字表法分为研究组、对照组,各52例。对照组采用常规治疗,研究组在对照组基础上加用辅酶Q10辅助治疗。比较两组疗效、治疗期间不良反应发生率、治疗前后血压水平[收缩压(SBP)、舒张压(DBP)]、心电图指标[最长QT间期(QTmax)、最短QT间期(QTmin)、QT离散度(QTd)]、内皮细胞功能[一氧化氮(NO)、内皮素-1(ET-1)、血管舒张功能(FMD)]、氧化应激指标[丙二醛(MDA)、活性氧(ROS)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)]。结果研究组总有效率高于对照组(P<0.05);治疗后,研究组SBP、DBP、QTd、ET-1、MDA、ROS低于对照组,QTmin、QTmax、FMD、NO、GSH-Px、SOD高于对照组,差异均有统计学意义(P<0.05);两组各不良反应发生率比较,差异均无统计学意义(P>0.05)。结论辅酶Q10辅助治疗老年高血压合并心律失常患者效果显著,且安全性较高,其机制可能与改善内皮细胞功能及减轻机体氧化应激状态有关。Objective To explore the efficacy and mechanism of coenzyme Q10 in the treatment of older patients with hypertension and arrhythmia.Methods A prospective study was conducted on 104 older patients with hypertension and arrhythmia admitted to hospital from June 2019 to February 2021.According to the random number table,the patients were divided into a study group(52 cases)and a control group(52 cases).The control group was treated with conventional treatment,and the study group was treated with conventional treatment and coenzyme Q10.The following data were compared between the two groups before and after treatment,including the efficacy,incidence of adverse reactions,blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)],ECG indicators[maximum QT interval(QTmax),minimum QT interval(QTmin),QT dispersion(QTd)],endothelial cell function[nitric oxide(NO),endothelin-1(ET-1),flow mediated dilation(FMD)],oxidative stress indicators[malondialdehyde(MDA),reactive oxygen species(ROS),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)].Results The overall response rate in the study group was higher than that in the control group(P<0.05).After treatment,the study group had lower levels of SBP,DBP,QTd,ET-1,MDA and ROS,and higher levels of QTmin,QTmax,FMD,NO,GSH-Px and SOD compared with the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Coenzyme Q10 shows significant efficacy and high safety in the treatment of older hypertensive patients with arrhythmia.The mechanism may be related to improving endothelial cell function and reducing oxidative stress.

关 键 词：辅酶Q10 高血压 心律失常 内皮细胞功能 心电图 

分 类 号：R544.1[医药卫生—心血管疾病] R541.7[医药卫生—内科学]