药物涂层球囊与普通球囊治疗股腘动脉硬化闭塞症的效果比较  

Comparison of effect of drug-coated balloon versus ordinary balloon on femoral popliteal arteriosclerosis obliterans disease

作　　者：徐良[1] 李金旭 李佩佩 王晓东[1] Xu Liang;Li Jinxu;Li Peipei;Wang Xiaodong(Department of Vascular Surgery,Nanyang Second People’s Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第二人民医院血管外科,南阳473000

出　　处：《中国实用医刊》2022年第23期22-25,共4页Chinese Journal of Practical Medicine

摘　　要：目的比较药物涂层球囊(DCB)与普通球囊治疗股腘动脉硬化闭塞症(FPAOD)的临床效果。方法抽取2018年12月至2021年12月南阳市第二人民医院收治的80例FPAO患者,按随机数字表法分为DCB组(40例)和普通组(40例)。两组患者均行经皮腔内血管成形术(PTA)治疗,其中DCB组术中采用DCB治疗,普通组术中采用普通球囊治疗。术后6个月,行踝臂指数(ABI)检查评估临床疗效;采用下肢动脉多普勒超声测量并计算支架内再狭窄(ISR)率;采用动脉超声和CT血管成像检查评估血管畅通情况,记录患者靶血管最小直径(MLD)、靶血管晚期管腔丢失(LLL)情况;于术前1 d及术后6个月,采用下肢缺血卢瑟福(Rutherford)分级评估患者病情严重程度;记录术后并发症发生情况。结果DCB组临床有效率(95.00%,38/40)高于普通组(80.00%,32/40),P<0.05;DCB组ISR率(2.50%,1/40)低于普通组(15.00%,12/40),P<0.05。DCB组患者MLD和ABI大于普通组,LLL小于普通组(P<0.05)。术前,两组患者不同Rutherford分级情况比较差异未见统计学意义(P<0.05);术后6个月,两组患者不同Rutherford分级明显改善,且DCB组改善情况优于普通组(P<0.05)。两组患者术后感染发生率、穿刺部位血肿发生率、肾功能受损发生率和血栓形成发生率比较,差异未见统计学意义(P>0.05)。结论DCB治疗FPAOD病变患者疗效较好,可降低ISR率并控制管腔丢失,改善病情严重程度,且安全性较好。Objective To compare the curative effect of drug-coated balloon(DCB)and ordinary balloon on femoral popliteal arteriosclerosis obliterans disease(FPAOD).Methods A total of 80 patients with FPAOD admitted to Nanyang Second People’s Hospital from December 2018 to December 2021 were selected.And they were divided into DCB group(40 cases)and ordinary group(40 cases)by random number table method.Both groups were treated by percutaneous transluminal angioplasty(PTA);the DCB group was treated by DCB during operation,while the ordinary group was treated by ordinary balloon.The clinical curative effect was evaluated by ankle-brachial index(ABI)6 months after surgery.The rate of in-stent restenosis(ISR)was measured by lower extremity Doppler ultrasound.The vessels patency was evaluated by arterial ultrasound and CT angiography.The minimum luminal diameter(MLD)and late luminal loss(LLL)of target vessels were recorded.Disease severity of was assessed by Rutherford classification of lower extremity ischemia(Rutherford)1 day before surgery and 6 months after surgery.The occurrence of postoperative complications was recorded.Results The clinical response rate of the DCB group(95.00%,38/40)was significantly higher than that of the ordinary group(80.00%,32/40),P<0.05;and rate of ISR in the DCB group(2.50%,1/40)was significantly lower than that in the ordinary group(15.00%,12/40),P<0.05.MLD and ABI in the DCB group were significantly higher than those in the ordinary group,while LLL was significantly lower than that in the ordinary group(P<0.05).Before surgery,there was no significant difference between the two groups in Rutherford grading(P<0.05).Every Rutherford grading was significantly improved 6 months after surgery in the two groups,and the improvement in the DCB group was superior to that in the ordinary group(P<0.05).There was no significant difference in the incidence of postoperative infection,hematoma at the puncture site,renal function impairment and thrombosis between the two groups(P>0.05).Conclusions Curative effe

关 键 词：药物涂层球囊 股腘动脉硬化闭塞症 支架内再狭窄 疗效 

分 类 号：R654.4[医药卫生—外科学]