线粒体ATP敏感钾通道与线粒体自噬对心力衰竭的作用研究  

The Role of Mitochondrial ATP-Sensitive Potassium Channel and Mitophagy in Heart Failure

作　　者：程晓蔚 朱庆磊[2] CHENG Xiaowei;ZHU Qinglei(Chinese PLA Medical School,Beijing 100853,China;Medical Department of Cardiovascular Disease,The Sixth Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第六医学中心心血管病医学部,北京100853

出　　处：《心血管病学进展》2023年第2期163-166,171,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81570349)。

摘　　要：心力衰竭是由心脏的收缩和/或舒张功能发生障碍,导致心室泵血功能受损引起的循环障碍症候群。临床主要表现为呼吸困难、咳嗽和咳痰。心力衰竭是心脏疾病发展的终末阶段,患者预后较差,目前心力衰竭的发病机制尚不完全明确。近年来,许多研究表明线粒体功能障碍与心力衰竭的发生发展密切相关。现对线粒体ATP敏感钾通道以及线粒体自噬对心力衰竭的作用进展进行综述。Heart failure is a circulatory disorder syndrome caused by impairment of the systolic and/or diastolic function of the heart,resulting in impaired ventricular pumping function.The main clinical manifestations are dyspnea,cough and sputum.Heart failure is the end stage of the development of heart disease with poor prognosis.Until now,the pathogenesis of heart failure is not fully clarified.In recent years,many studies have shown that mitochondrial dysfunction is closely related to the occurrence and development of heart failure.In this article,we reviewed the progress of mitochondrial ATP-sensitive potassium channels and the role of mitophagy in heart failure.

关 键 词：心力衰竭 线粒体ATP敏感钾通道 线粒体自噬 

分 类 号：R541.6[医药卫生—心血管疾病]