心肌细胞铁死亡及其检测方法  

Methods for Detection of Ferroptosis in Cardiomyocytes

作　　者：孙悦 付松波 李亦兰 SUN Yue;FU Songbo;LI Yilan(Institute of Keshan Disease,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,Heilongjiang,China;Department of Cardiology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学中国疾病预防控制中心地方病控制中心克山病防治研究所,黑龙江哈尔滨150081 [2]哈尔滨医科大学附属第二医院心血管内科,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2023年第2期167-171,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金青年科学基金(82000381);黑龙江省博士后基金面上项目(LBH-Z19188)。

摘　　要：铁死亡是一种新型程序性细胞死亡方式。近年来研究发现,铁死亡在心脏疾病的发生发展中发挥了重要作用。随着心肌细胞铁死亡领域的深入研究,人们对心肌细胞铁死亡检测的精确性和可重复性的关注度日益增加,揭示心肌细胞铁死亡的详细分子机制及开发精确的铁死亡检测方法具有极其重要的指导意义与临床价值。现对目前研究中识别、测量和评估心肌细胞铁死亡的最佳方法加以综述。Ferroptosis is a new way of programmed cell death.In recent years,it has been found that ferroptosis plays an important role in the occurrence and development of heart disease.Following the deep research in the field of cardiomyocytes ferroptosis,people pay more attention to the accuracy and repeatability of the detection of myocardial cell ferroptosis,which is of great significance to the research on the mechanism and detection method of cardiomyocyte ferroptosis.In this article,we summarize the best methods to identify,measure and evaluate ferroptosis in cardiomyocytes.

关 键 词：心肌细胞 铁死亡 细胞死亡 检测方法 

分 类 号：R54[医药卫生—心血管疾病]