直接三氟甲硒基化反应研究进展  

Research Progress on Direct Trifluoromethylselenylation

作　　者：胡朝明 吴纪红 吴晶晶 吴范宏 Hu Zhaoming;Wu Jihong;Wu Jingjing;Wu Fanhong(Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology,School of Chemical and Environmental Engineering,Shanghai Institute of Technology,Shanghai 201418)

机构地区：[1]上海应用技术大学化学与环境工程学院、上海绿色氟代制药工程技术研究中心,上海201418

出　　处：《有机化学》2023年第1期36-56,共21页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21672151,21602136)资助项目。

摘　　要：三氟甲硒基化反应是近几年继三氟甲硫基化反应后的又一重要研究课题,由于三氟甲硒基同时包含氟和硒这两种重要的化学元素,并且含三氟甲硒基的化合物具有重要的潜在生物活性,因此近年来越来越多的科研工作者开始把目光转向这一新兴基团.此综述按照亲核三氟甲硒基化反应、亲电三氟甲硒基化反应、自由基三氟甲硒基化反应三种反应类型,对近6年来的国内外学者在直接三氟甲硒基化反应的研究进行了全面总结,并对部分反应机理进行详细的论述,最后对直接三氟甲硒基化反应进行了总结和展望.The trifluoromethylselenylation reaction is another important research topic after trifluoromethylsulfanylation reaction in recent years.Because the trifluoromethylselenyl group contains two important chemical elements,fluorine and selenium,and the compounds containing trifluoromethyl selenide have important potential biological activities,more and more researchers begin to turn their attention to this new group in recent years.In this paper,according to the three reaction types of nucleophilic trifluoromethylselenylation reaction,electrophilic trifluoromethylselenylation reaction and radical trifluoromethylselenylation reaction,the research results of domestic and foreign scholars on direct trifluoromethylselenylation reaction in recent 6 years are comprehensively summarized,and some reaction mechanisms are discussed in detail.Finally,the direct trifluoromethylselenylation reaction is summarized and prospected.

关 键 词：三氟甲硒基 亲核反应 亲电反应 自由基反应 

分 类 号：O621.25[理学—有机化学]