可见光促进N-氟代酰胺的1,5-氢迁移和自由基偶联反应合成联苄基衍生物  

Synthesis of Bibenzyl Derivatives via Visible-Light-Promoted 1,5-Hydrogen Atom Transfer/Radical Coupling Reactions of N-Fluorocarboxamides

作　　者：雷盼盼 陈沁琳 陈航 周洋 敬林海[1] 汪伟 陈芬儿 Lei Panpan;Chen Qinlin;Chen Hang;Zhou Yang;Jin Linhai;Wang Wei;Chen Fener(College of Chemistry and Chemical Engineering,China West Normal University,Nanchong,Sichuan 637002;Pharmaceutical Research Institute,Wuhan Institute of Technology,Wuhan 430205;Department of Chemistry,Fudan University,Shanghai 200433)

机构地区：[1]西华师范大学化学化工学院,四川南充637002 [2]武汉工程大学药物研究院,武汉430205 [3]复旦大学化学学院,上海200433

出　　处：《有机化学》2023年第1期254-264,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21602144);四川省科技计划(No.2021ZYD0064);湖北省教育厅科研计划(No.Q20211503)资助项目。

摘　　要：报道了光催化N-氟代苯甲酰胺的1,5-氢原子转移和苄基自由基的偶联反应.该反应表现出了良好的底物适用性和官能团兼容性,以较好的产率得到了一系列重要的联苄基类化合物.更重要的是,该方法也适用于N-氟代的脂肪族酰胺.Visible light-mediated 1,5-hydrogen atom transfer and radical coupling reactions have been accomplished using N-fluoro-substituted benzamides. This method exhibits a broad substrate scope and high functional group tolerance, giving the corresponding bibenzyl products with generally good yields. Furthermore, this strategy could also be used to N-fluoro-substituted aliphatic amides.

关 键 词：联苄基衍生物 1 5-氢迁移 自由基偶联 可见光 

分 类 号：O621.251[理学—有机化学]