不同剂量红霉素联合多潘立酮治疗功能性消化不良患儿的效果比较  

Comparison of Different Doses of Erythromycin Combined with Domperidone in the Treatment of Children with Functional Dyspepsia

作　　者：郑艺兵 王健 蔡冬冬 ZHENG Yibing;WANG Jian;CAI Dongdong(Zhangzhou Second Hospital,Zhangzhou 363200,China;不详)

机构地区：[1]漳州市第二医院,福建漳州363200 [2]漳州市医院

出　　处：《中外医学研究》2023年第7期39-42,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨不同剂量红霉素联合多潘立酮治疗功能性消化不良(FD)患儿的效果。方法:选取2020年8月—2022年8月漳州市第二医院收治的FD患儿96例,根据随机数表法将其分为大剂量组和小剂量组,各48例。大剂量组予以大剂量红霉素(10~15 mg/kg)联合多潘立酮治疗,小剂量组予以小剂量红霉素(3~5 mg/kg)联合多潘立酮治疗,两组均持续治疗1周。观察比较两组的临床效果、症状消失时间、复发率、不良反应发生率;比较治疗前后两组的血清一氧化氮(NO)、促胃液素(GAS)水平。结果:治疗1周后,小剂量组的总有效率为95.83%,高于大剂量组的81.25%,差异有统计学意义(P<0.05);用药后,小剂量组临床症状消失时间早于大剂量组,差异有统计学意义(P<0.05);用药期间,小剂量组出现腹泻、乏力等不良反应的发生率为4.17%,低于大剂量组的16.67%,差异有统计学意义(P<0.05);治疗1周后,两组的NO、GAS水平高于治疗前,且小剂量组的NO、GAS水平高于大剂量组,差异有统计学意义(P<0.05)。结论:小剂量红霉素联合多潘立酮治疗FD相比大剂量红霉素联合治疗对于改善FD患儿的效果更好,并且可以有效调节患儿血清NO、GAS水平,安全性好。Objective:To explore the clinical effect of different doses of Erythromycin combined with Domperidone on children with functional dyspepsia(FD).Method:A total of 96 children with FD admitted to Zhangzhou Second Hospital from August 2020 to August 2022 were divided into high-dose group and low-dose group according to the method of random number table,with 48 cases in each group.The high-dose group was treated with high-dose Erythromycin(10-15 mg/kg)combined with Domperidone,while the lowdose group was treated with low-dose Erythromycin(3-5 mg/kg)combined with Domperidone.Both groups continued to be treated for 1week.Observed and compared the clinical effect,time of symptom disappearance,recurrence rate and adverse reaction rate of the two groups.The levels of serum nitric oxide(NO)and gastrin(GAS)were compared between the two groups before and after treatment.Result:After one week of treatment,the total effective rate in the low-dose group was 95.83%,which was higher than 81.25%in the high-dose group,the difference was statistically significant(P<0.05).After medication,the clinical symptoms of the low-dose group disappeared earlier than that of the high-dose group,and the difference was statistically significant(P<0.05).During the medication,the incidence of diarrhea,fatigue and other adverse reactions in the low-dose group was 4.17%,which was lower than 16.67%in the high-dose group,the difference was statistically significant(P<0.05).After one week of treatment,the levels of NO and GAS in the two groups were higher than those before treatment,and the levels of NO and GAS in the low-dose group were higher than those in the high-dose group,the differences were statistically significant(P<0.05).Conclusion:Compared with high-dose Erythromycin combined with Domperidone in the treatment of FD,low-dose Erythromycin combined with Domperidone has a better effect on improving the children with FD,and can effectively regulate the level of serum NO and GAS in children,with good safety.

关 键 词：不同剂量红霉素 多潘立酮 功能性消化不良 一氧化氮 促胃液素 临床效果 

分 类 号：R725.7[医药卫生—儿科]