潮汕地区4123对不孕不育夫妇病因及治疗效果  

Causes and therapeutic effect of 4 123 pairs of infertility couples in Chaoshan area

作　　者：王柏菊 苏中静[2] WANG Baiju;SU Zhongjing(Reproductive Medicine Center,Jieyang Aiwei Ive Hospital,Guangdong Province,Jieyang 522000,China;Shantou University Medical College,Guangdong Province,Shantou 515041,China)

机构地区：[1]广东省揭阳爱维艾夫医院生殖医学中心,广东揭阳522000 [2]汕头大学医学院,广东汕头515041

出　　处：《中国当代医药》2023年第8期130-134,共5页China Modern Medicine

基　　金：广东省揭阳市科技计划项目(210922166991628)。

摘　　要：目的分析潮汕地区不孕不育的病因以及各因素下的临床妊娠结局,旨在为不孕症的治疗和预防提供依据。方法选取2014年1月1日至2019年12月30日在广东省揭阳爱维艾夫医院生殖医学中心就诊进行辅助生殖技术的4123对不孕不育夫妇的资料进行回顾性分析。行体外受精-胚胎移植(IVF-ET)治疗3715例,其中原发性不孕1992例(53.62%),继发性不孕1723例(46.38%);女性不孕2934例,男性不育512例,双方因素269例。行宫腔人工授精408例。分析不孕不育因素的构成以及不同治疗方法的妊娠率。结果4123对夫妇中,患病年限1~<4年者占比最高,为43.17%。3715例行IVF-ET治疗患者中,原发性不孕的多囊卵巢综合征(PCOS)、子宫因素占比均高于继发性不孕,差异均有统计学意义(P<0.05)。原发性不孕的输卵管因素和卵巢储备功能减退占比低于继发性不孕,差异均有统计学意义(P<0.05)。行IVF-ET治疗女性不孕患者中,输卵管因素为主要原因,占比为61.05%。行IVF-ET治疗男性不育患者中,畸形精子症的占比较高,为30.39%。PCOS因素不孕行IVF-ET治疗患者的妊娠率高于输卵管因素,子宫因素、子宫内膜异位症、卵巢储备功能减退、其他排卵异常不孕行IVF-ET治疗患者的妊娠率均低于输卵管因素,差异均有统计学意义(P<0.05)。PCOS因素不孕行IVF-ET治疗患者的妊娠率最高(81.43%)。弱精子症不育行IVF-ET治疗患者的妊娠率低于无精子症,差异有统计学意义(P<0.05)。畸形精子症不育行IVF-ET治疗患者的妊娠率较高(72.22%)。不同原因的不孕不育患者选择宫腔人工授精的妊娠率比较,差异无统计学意义(P>0.05)。结论不孕不育原因涉及男女双方,其中女方不孕病因复杂,辅助生殖技术针对不同的不孕不育病因具有不同的成功率。Objective To analyze the etiology and clinical pregnancy outcome of infertility in Chaoshan area,to provide the basis for the treatment and prevention of infertility.Methods A retrospective analysis was conducted on the data of 4123 pairs of infertility couples who received assisted reproductive technology at the Reproductive Medicine Center of Jieyang Aiwei Ive Hospital,Guangdong Province from January 1,2014 to December 30,2019.A total of 3715 cases of in vitro fertilization embryo transfer(IVF-ET)were treated,including 1992 cases(53.62%)of primary infertility and 1723 cases(46.38%)of secondary infertility.A total of 2934 cases of female infertility,512 cases of male infertility,and 269 cases of both factors.A total of 408 patients underwent intrauterine artificial insemination.To analyze the composition of infertility factors and the pregnancy rate of different treatment methods.Results Among 4123 pairs of infertility couples,the highest proportion(43.17%)was those who had the disease for 1 to<4 years.In 3715 patients treated with IVF-ET,the proportion rates of polycystic ovarian syndrome(PCOS),uterine factors in primary infertility were higher than those in secondary infertility,and the differences were statistically significant(P<0.05).The proportion rates of tubal factors and decreased ovarian reserve function in primary infertility were lower than those in secondary infertility,and the differences were statistically significant(P<0.05).Tubal factor was the main cause of infertility in female patients treated with IVF-ET,accounting for 61.05%.Among the male infertility patients treated with IVF-ET,the proportion of malformed spermia was relatively high,accounting for 30.39%.The pregnancy rate of PCOS infertility patients treated with IVF-ET was higher than that of tubal factors,and the pregnancy rates of uterine factors,endometriosis,decreased ovarian reserve function and other ovulation abnormalities patients treated with IVF-ET were lower than those of tubal factors,with statistical significances(P<0.05).T

关 键 词：不孕不育 体外受精-胚胎移植 宫腔人工授精 妊娠结局 

分 类 号：R711.74[医药卫生—妇产科学]