芽孢杆菌嗜铁素研究进展  

Research progress of siderophore produced by Bacillus spp

作　　者：刘邮洲[1] 沈佳慧 乔俊卿[1] 左杨 刘永锋[1] LIU You-zhou;SHEN Jia-hui;QIAO Jun-qing;ZUO Yang;LIU Yong-feng(Institute of Plant Protection,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China)

机构地区：[1]江苏省农业科学院植物保护研究所,江苏南京210014

出　　处：《江苏农业学报》2023年第1期266-276,共11页Jiangsu Journal of Agricultural Sciences

基　　金：江苏省农业科技自主创新基金项目[CX(21)3096];国家自然科学基金项目(32272624)。

摘　　要：嗜铁素(Siderophore)是微生物为适应自然界高氧低铁环境,产生的一类能特异性螯合三价铁离子的小分子化合物。绝大多数细菌和真菌都能通过非核糖体肽合成酶途径(NRPS)或非依赖NRPS途径(NIS)合成一种或几种嗜铁素。芽孢杆菌是目前研究与生产上应用最多的一类生防细菌,但芽孢杆菌嗜铁素的生防贡献国内外鲜有报道。本文对芽孢杆菌嗜铁素的种类、合成与调控机制、功能与应用(包括竞争作用、抗生作用、毒力作用、环境污染修复作用以及在医药研发上的应用等)进行了系统概述,为解析自然界中芽孢杆菌具有广谱抗菌活性的生防机制提供理论依据,同时对研发嗜铁素和药物偶联的新型靶向农药具有重要指导意义。Iron is an essential element for the growth of almost all living microorganisms because it acts as a cofactor in enzymatic processes,oxygen metabolism,electron transfer,and RNA syntheses.Although iron is abundant in the earth’s crust,it exists primarily as insoluble hydroxides in aerobic aqueous solution,making its acquisition difficult for microorganisms.To overcome this challenge,many microorganisms secrete low molecular weight iron chelators called siderophores.Most bacteria and fungi can synthesize one or more siderophores through nonribosomal peptide synthetases(NRPS)pathway or NRPS-independent siderophore(NIS)pathway.Bacillus spp.is considered the most successful biological control agent.However,there are few reports on the research of siderophore produced by Bacillus spp.In this paper,the types,biosynthesis and regulation mechanisms,functions and applications of siderophore produced by Bacillus spp.were systematically summarized,including competition,antibiosis,virulence,environmental pollution remediation and pharmaceutical research and development.Our results will reveal the new biological control mechanism of Bacillus spp.based on siderophore,which will help to expand the biocontrol application of siderophore and develop new target biological pesticides.

关 键 词：芽孢杆菌 嗜铁素 嗜铁素药物耦合物 

分 类 号：S482.39[农业科学—农药学]