呼吸道吸入药物递送系统的研究进展  

Recent progress of respiratory inhalation drug delivery systems

作　　者：何明欣 周向东[2,3] 徐立 张娜[1,4] 周明[1,4] 骆丁 张华 李琪 HE Ming-xin;ZHOU Xiang-dong;XU Li;ZHANG Na;ZHOU Ming;LUO Ding;ZHANG Hua;LI Qi(International Nursing College of Hainan Medical University,Haikou 571199,China;Department of Respiratory Medicine,the First Affiliated Hospital of Hainan Medical College,Haikou 570102,China;National Health Commission Key Laboratory of Tropical Disease Control,Hainan Medical University,Hainan 571199,China;Research Unit of Island Emergency Medicine,Chinese Academy of Medical Sciences,Haikou 571199,China;Key Laboratory of Emergency and Trauma,Ministry of Education,Haikou 571199,China)

机构地区：[1]海南医学院国际护理学院,海南海口571199 [2]海南医学院第一附属医院呼吸内科,海南海口570102 [3]国家卫生健康委热带病防治重点实验室,海南海口571199 [4]中国医学科学院海岛急救医学创新单元,海南海口571199 [5]海南医学院急救与创伤研究教育部重点实验室,海南海口571199

出　　处：《海南医学院学报》2023年第5期395-400,共6页Journal of Hainan Medical University

基　　金：海南省创新团队项目(820CXTD448);海南省重点研发计划国际科技合作项目(GHYF2022011);海南省重点研发项目(ZDYF2020223);海南省重大科技专项(ZDKJ2021036);海南省自然科学基金高层次人才项目(2019RC212);中国医学科学院医学与健康科技创新工程项目(2019-12M-5-023);海南省重大科技计划项目(ZDKJ2021039、ZDKJ202004);海南医学院教育科研课题立项项目重点课题(HYZD202111);国家自然科学基金(81860001、82011530049、82160012);国家卫生健康委员会热带病防治重点实验室开放课题(2021NHCTDCKFKT21008);海南省临床医学中心建设项目基金。

摘　　要：随着人口老龄化、吸烟人群年轻化以及空气污染严重化等诸多因素的影响,慢性呼吸道疾病发病率也逐年增多。在呼吸道疾病的治疗手段中,临床干预仍以药物治疗为主。然而,全身用药存在不良反应多及全身副作用大等弊端。近年来,呼吸道吸入药物递送系统的研发为呼吸道疾病的治疗手段带来了新的变革,局部递送药物可直接作用于气道,具有起效快、疗效好且副作用小等特点,对控制气道疾病起到十分显著的效果,是一种简单、高效、安全的治疗手段,业已成为当下研究及推广的热点方向。本文就国内外关于呼吸道吸入药物递送系统的发展轨迹及最新研究进展作一简要综述,以期为临床工作者在用药的选择和应用方面提供参考借鉴。With the influence of many factors such as the aging of the population, the younger smokers, and the serious air pollution, the incidence of chronic respiratory diseases is increasing year by year. In the treatment of respiratory diseases, clinical intervention is still mainly based on drug control of pulmonary symptoms. However, systemic drugs have disadvantages such as many adverse reactions and severe systemic side effects. In recent years, the research and development of local drug delivery systems for the respiratory tract has brought new changes to the treatment of respiratory diseases. Locally delivered drugs can directly act on the airways and have the characteristics of fast onset, good curative effect and small side effects. It is a simple, efficient and safe treatment method, which has a very significant effect, and has become a hot topic of current research and promotion. This paper briefly reviews the development track and latest research progress of respiratory local drug delivery systems at home and abroad, in order to provide reference for clinical workers in drug selection and application.

关 键 词：呼吸道疾病 吸入制剂 药物递送系统 局部用药 综述 

分 类 号：R943[医药卫生—药剂学]