带状疱疹后神经痛动物模型及其机制研究新进展  

New progress in animal model and mechanism of postherpetic neuralgia

作　　者：吴松斌 杨少敏 黄佳彬 孙武平 熊东林 肖礼祖 WU Songbin;YANG Shaomin;HUANG Jiabin;SUN Wuping;XIONG Donglin;XIAO Lizu(Department of Pain Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen Key Laboratory of Pain Medicine,Nanshan Hospital,Shenzhen 518052,China)

机构地区：[1]华中科技大学协和深圳医院疼痛科,深圳市疼痛学实验室,深圳518052

出　　处：《中国疼痛医学杂志》2023年第2期84-91,共8页Chinese Journal of Pain Medicine

基　　金：深圳市卫南山区技术研发和创意设计项目分项资金(NS2022019);华中科技大学协和深圳医院院内课题(YN2022027)。

摘　　要：带状疱疹后神经痛(postherpetic neuralgia,PHN)是由水痘-带状疱疹病毒(varicella zoster virus,VZV)感染所引起的常见并发症,多见于老年人和免疫功能低下者,严重影响病人的身心健康和生活质量。尚未明确的致病机制让PHN治疗效果欠佳,缺乏有效模拟PHN的动物模型更让PHN发病机制的研究止步不前。本文主要综述目前PHN动物模型构建的研究进展,重点介绍由VZV与单纯疱疹病毒1型(herpes simplex virus 1,HSV-1)诱导的PHN动物模型的建立方法和疼痛行为学表现。旨在比较现有PHN动物模型的研究概况,为进一步阐明PHN致病机制提供有效的研究工具,同时也为PHN动物模型的选择和改良提供参考。Postherpetic neuralgia(PHN)is a common complication caused by varicella zoster virus(VZV)infection,which is more common in the elderly and immunocompromised patients,and seriously affects the physical and mental health and quality of life of patients.The unclear pathogenesis makes PHN treatment ineffective,and the lack of effective animal models to simulate PHN makes the research progress of PHN pathogenesis stagnant.This review mainly introduced the research progress on the make of PHN animal models,focused on the establishment methods and pain behaviors of PHN animal models induced by VZV and herpes simplex virus 1(HSV-1).It aims to compare the current research status of PHN animal models,provides effective research tools for further elucidating the pathogenic mechanism of PHN,and provide references for the selection and improvement of PHN animal models.

关 键 词：带状疱疹后神经痛 动物模型 水痘-带状疱疹病毒 单纯疱疹病毒I型 病理机制 

分 类 号：R752.12[医药卫生—皮肤病学与性病学] R-332[医药卫生—临床医学]