超声造影结合血清IL-6、MMPs对颈动脉大动脉炎活动性的诊断分析  

Diagnostic Analysis of Contrast-Enhanced Ultrasound Combined with Serum IL-6 and MMPs in the Activity of Carotid Arteritis

作　　者：吕娟[1] 万静[1] 于鲁欣 张利[1] LV Juan;WAN Jing;YU Lu-xin;ZHANG Li(People's Hospital of Xinjiang Uygur Autonomous Region Ultrasonography Department,Urumqi 830000,Xinjiang,China)

机构地区：[1]新疆维吾尔自治区人民医院超声科,新疆乌鲁木齐830000

出　　处：《中国CT和MRI杂志》2023年第3期44-46,共3页Chinese Journal of CT and MRI

基　　金：新疆维吾尔自治区自然科学基金(2021D01C179)。

摘　　要：目的分析超声造影结合血清白介素-6(IL-6)、基质金属蛋白酶-3(MMP-3)、基质金属蛋白酶-9(MMP-9)水平对颈动脉大动脉炎活动性的诊断价值。方法选取本院2017年10月至2021年4月收治的127例颈动脉大动脉炎患者记作疾病组,另于同期招募124例健康志愿者记作健康组。疾病组均予以超声造影检查,且2组均采用酶联免疫法检测血清IL-6、MMP-3、MMP-9水平。疾病组根据活动性分为活动期组和非活动期组。比较疾病组与健康组血清IL-6、MMP-3、MMP-9水平;比较活动期组和非活动期组超声造影参数与血清IL-6、MMP-3、MMP-9水平;分析超声造影参数与血清IL-6、MMP-3、MMP-9水平结合对颈动脉大动脉炎活动性的诊断价值。结果:疾病组血清IL-6、MMP-3、MMP-9水平均高于健康组(P<0.05),且活动期组血清IL-6、MMP-3、MMP-9水平均高于非活动期组(P<0.05),活动期组超声造影主要表现:受累节段增厚,类比凹凸不平,似斑块样,且增厚管壁及内膜可见大量造影剂光点进入,且活动期组平均回声强度(EI)、峰值强度(DPI)、内-中膜厚度(IMT)均高于非活动期组(P<0.05);超声造影参数结合血清IL-6、MMP-3、MMP-9水平诊断颈动脉大动脉炎活动期的灵敏度高于单独诊断(P<0.01),受试者工作特征(ROC)曲线下面积高于单独诊断(P<0.05),特异度与单独诊断差异均无统计学意义(P>0.05)。结论颈动脉大动脉炎患者血清IL-6、MMP-3、MMP-9水平升高,且超声造影参数中IMT、EI和DPI、上述血清学指标均与疾病活动性有关,上述指标结合诊断疾病活动性的效能高。Objective To analyze the diagnostic value of contrast-enhanced ultrasound combined with serum levels of interleukin-6(IL-6),matrix metalloproteinase-3(MMP-3)and matrix metalloproteinase-9(MMP-9)in the activity of carotid arteritis.Methods 127 patients with carotid arteritis admitted to our hospital from October 2017 to April 2021 were selected as the disease group,and 124 healthy volunteers were recruited as the healthy group at the same time.The disease group were given contrast-enhanced ultrasound examination,and the serum levels of IL-6,MMP-3 and MMP-9 were detected by enzymelinked immunosorbent assay.The disease group was divided into active group and inactive group according to activity.The serum levels of IL-6,MMP-3 and MMP-9 were compared between the disease group and the healthy group.The contrast-enhanced ultrasound parameters and serum levels of IL-6,MMP-3 and MMP-9 were compared between the active and inactive groups.To analyze the diagnostic value of contrast-enhanced ultrasound parameters combined with serum IL-6,MMP-3 and MMP-9 levels in the activity of carotid arteritis.Results The levels of serum IL-6,MMP-3 and MMP-9 in the disease group were higher than those in the healthy group(P<0.05),and the levels of serum IL-6,MMP-3 and MMP-9 in the active group were higher than those in the inactive group(P<0.05).The main manifestations of contrast-enhanced ultrasound in the active group,the involved segments were thickened,similar to uneven,plaque like,and a large number of contrast medium light spots could be seen in the thickened tube wall and intima.The average echo intensity(EI),peak intensity(DPI)and intima-media thickness(IMT)of the active group were higher than those of the inactive group(P<0.05).The sensitivity of contrast enhanced ultrasound parameters combined with serum IL-6,MMP-3 and MMP-9 levels in the diagnosis of active carotid arteritis was higher than that of single diagnosis(P<0.01),and the area under receiver operating characteristic(ROC)curve was higher than that of single diagnosis(P<

关 键 词：超声造影 白介素-6 基质金属蛋白酶-3 基质金属蛋白酶-9 颈动脉大动脉炎 疾病活动性 

分 类 号：R445.1[医药卫生—影像医学与核医学]