奥曲肽联合灯盏花素注射液治疗重症急性胰腺炎的效果及对血清TNF-α、IL-8、ICAM-1的影响  

Efficacy of octreotide combined with breviscapine injection on severe acute pancreatitis and its influence on serum levels of TNF-α,IL-8 and ICAM-1

作　　者：乔茶 乔磊 张文博 王贺帅 QIAO Cha;QIAO Lei;ZHANG Wenbo(Department of Digestive Medicine,The No.2 Hospital of Baoding,Hebei,Baoding 071052,China;不详)

机构地区：[1]河北省保定市第二医院消化内科,071052 [2]河北省保定市第二医院骨二科,071052 [3]河北省保定市第二医院内分泌科,071052

出　　处：《河北医药》2023年第2期242-244,248,共4页Hebei Medical Journal

摘　　要：目的 研究奥曲肽联合灯盏花素注射液治疗重症急性胰腺炎(SAP)的疗效及对血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、细胞间黏附分子-1(ICAM-1)的影响。方法 选取2019年1月至2020年6月收治的100例SAP患者随机均分为观察组(奥曲肽联合灯盏花素注射液治疗)和对照组(奥曲肽治疗)每组50例,比较2组疗效、临床症状恢复时间,比较两组治疗前及治疗10 d后炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、细胞间黏附分子-1(ICAM-1)]、疾病相关因子[血栓素B2(TXB2)、可溶性髓系细胞触发受体-1(sTREM-1)、血管性血友病因子(vWF)]水平,比较2组并发症发生情况。结果 2组总有效率比较差异无统计学意义(P>0.05)。观察组腹痛消失时间、上腹部压痛恢复时间、体温恢复时间、恶心呕吐恢复时间均明显低于对照组(P<0.05)。治疗10 d后,观察组炎性因子(TNF-α、IL-8、ICAM-1)、疾病相关因子(TXB2、sTREM-1、vWF)水平明显低于治疗前及同期对照组(P<0.05)。2组败血症、肾衰竭、多器官衰竭、呼吸窘迫综合征、休克发生率比较差异无统计学意义(P>0.05)。结论 奥曲肽联合灯盏花素注射液治疗SAP具有良好疗效,能够有效改善患者症状,降低患者炎性水平。Objective To study the efficacy of octreotide combined with breviscapine injection on severe acute pancreatitis(SAP) and its influence on serum levels of tumor necrosis factor-α(TNF-α),interleukin-8(IL-8) and intercellular adhesion molecules-1(ICAM-1).Methods A total of 100 SAP patients admitted to our hospital from January 2019 to June 2020 were randomly assinged to observation group(octreotide combined with breviscapine injection) and control group(octreotide therapy),with 50 cases in each group.The efficacy and recovery times of clinical symptoms were assessed between the two groups.The levels of inflammatory factors,including TNF-α,IL-8 and ICAM-1,and disease-related factors,including the thromboxane B2(TXB2),soluble triggering receptor expressed on myeloid cells-1(sTREM-1),and von Willebrand factor(vWF) were compared between the two groups before treatment and 10 days after treatment.The incidence of complications was recorded.Results There was no significant difference in the total effective rate between the two groups(P>0.05).The disappearance time of abdominal pain,and the recovery time of upper abdominal tenderness,body temperature and nausea and vomiting in the observation group were significantly lower than those in control group(P<0.05).After 10 days of treatment,the levels of inflammatory factors(TNF-α,IL-8,ICAM-1) and disease-related factors(TXB2,sTREM-1,vWF) in the observation group were significantly lower than those before treatment and those in control group during the same period(P<0.05).There were no significant differences in the incidence rates of sepsis,renal failure,multiple organ failure,respiratory distress syndrome and shock between the two groups(P>0.05).Conclusion Octreotide combined with breviscapine injection has a good efficacy in the treatment of SAP,and it can effectively improve the symptoms and reduce the inflammation level.

关 键 词：奥曲肽 灯盏花素注射液 重症急性胰腺炎 肿瘤坏死因子-α 白细胞介素-8 细胞间黏附分子-1 

分 类 号：R657.51[医药卫生—外科学]